150969-56-5

Basic information

• Product Name: 5-(Trifluoromethyl)-1-indanone
• Synonyms: 5-(TRIFLUOROMETHYL)-2,3-DIHYDROINDEN-1-ONE,98%;5-(TRIFLUOROMETHYL)INDANONE;5-trifluormethyl-1-indanone;5-(Trifluoromethyl)-1-indanone;2,3-Dihydro-5-(trifluoromethyl)-1H-inden-1-one, 2,3-Dihydro-1-oxo-5-(trifluoromethyl)-1H-indene;5-(TrifluoroMethyl)-2,3-dihydro-1H-inden-1-one
• CAS NO: 150969-56-5
• Molecular Formula: C₁₀H₇F₃O
• Molecular Weight: 200.16
• Product Categories: Indanone & Indene
• Mol File: 150969-56-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 237.1 °C at 760 mmHg
• Flash Point: 95.3 °C
• Appearance: /
• Density: 1.347 g/cm³
• Vapor Pressure: 0.0458mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-(Trifluoromethyl)-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Trifluoromethyl)-1-indanone(150969-56-5)
• EPA Substance Registry System: 5-(Trifluoromethyl)-1-indanone(150969-56-5)

Safety Data

• Hazardous Substances Data: 150969-56-5(Hazardous Substances Data)

Usage

General Description

5-(Trifluoromethyl)-1-indanone is a chemical compound with the molecular formula C10H7F3O. It is a white to off-white solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 5-(Trifluoromethyl)-1-indanone is known for its unique structure and reactivity, making it useful in a variety of organic synthesis processes. It is important to handle 5-(Trifluoromethyl)-1-indanone with care, as it is considered hazardous to human health and the environment. Proper safety measures should be implemented when handling and storing this chemical to prevent any potential accidents or harm.

InChI:InChI=1/C10H7F3O/c11-10(12,13)7-2-3-8-6(5-7)1-4-9(8)14/h2-3,5H,1,4H2

Upstream product

• 201230-82-2 carbon monoxide 
• 40230-93-1 3-<(trimethylsilyl)ethynyl>benzotrifluoride 
• 828267-49-8 1-chloro-4-(trifluoromethyl)-2-vinylbenzene 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 511533-38-3 5-iodoindan-1-one 
• 3470-54-0 5-aminoindan-1-one 
• 102684-91-3 2-bromo-5-(trifluoromethyl)benzaldehyde 
• 1483-55-2 2-bromo-5-trifluoromethylbenzonitrile 
• 869725-54-2 1-bromo-2-(chloromethyl)-4-(trifluoromethyl)benzene 
• 869725-53-1 (2-bromo-5-(trifluoromethyl)phenyl)methanol 
• 869725-56-4 3-[2-bromo-5-(trifluoromethyl)phenyl]propanoic acid 

Downstream Products

• 869725-57-5 5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol 
• 1279722-79-0 C₁₇H₁₂F₃N₃ 
• 1279722-81-4 Br^(1-)*C₂₈H₂₃F₃P⁽¹⁺⁾ 

Relevant articles and documents

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

Microwave-enhanced carbonylative generation of indanones and 3-acylaminoindanones

(Chemical Equation Presented). The development of microwave-accelerated protocols for palladium(0)-catalyzed carbonylative cyclization of unsaturated aryl bromides and chlorides is described. By employing o-bromostyryl derivatives lacking substituents on the vinylic bond, molybdenum hexacarbonyl-mediated in situ carbonylation delivered a set of indan-1-one products in high yield after only 20 min of heating. Without the addition of the tri-tert-butylphosphine releasing Fu-salt ((t-Bu)3PHBF4), only incomplete conversions of sluggish o-styryl bromides and chlorides were realized. Internal and chemoselective palladium(0)-catalyzed Heck arylations of enamides afforded suitable starting materials for subsequent rapid ring-closing reactions. Microwave-heated intramolecular in situ carbonylation of these electron-rich and sterically congested olefins conveniently afforded eight functionalized 3-acylaminoindanone derivatives in a novel synthetic process. Attempted carbonylative annulation of electron-poor o-bromocinnamic acid derivatives furnished only the corresponding lactones via a competing hydroxycarbonylation- Michael addition reaction sequence.

Rhodium Complex-Catalyzed Desilylative Cyclocarbonylation of 1-Aryl-2-(trimethylsilyl)acetylenes: A New Route to 2,3-Dihydro-1H-inden-1-ones

Under water gas shift reaction conditions, 1-aryl-2-(trimethylsilyl)acetylenes undergo Rh-catalyzed desilylative cyclocarbonylation to give 2,3-dihydro-1H-inden-1-ones and trimethylsilanol.A wide variety of functional groups, such as methoxy, chloro, acetyl, ethoxycarbonyl, cyano, and trifluoromethyl, are tolerated on the aromatic ring under the reaction conditions.The products were obtained in good to excellent yield whether the substituent on the aromatic ring was electron-donating or electron-withdrawing.The cyclizations of substrates bearing a meta substituent onthe aromatic ring regiospecifically gave 5-substituted-2,3-dihydro-1H-inden-1-ones except when the meta substituent was a methoxy group.The desilylative cyclocarbonylation is an alternative to the conventional preparation of 2,3-dihydro-1H-inden-1-ones, an intramolecular Friedel-Crafts acylation.A possible mechanism for the process is described.