40232-93-7

Basic information

• Product Name: bis(4-hydroxyphenyl)acetic acid
• Synonyms: bis(4-hydroxyphenyl)acetic acid;2,2-Bis(4-hydroxyphenyl)acetic acid
• CAS NO: 40232-93-7
• Molecular Formula: C₁₄H₁₂O₄
• Molecular Weight: 244.24268
• EINECS: 254-850-4
• Mol File: 40232-93-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 465.6°Cat760mmHg
• Flash Point: 249.5°C
• Appearance: /
• Density: 1.375g/cm³
• Vapor Pressure: 1.81E-09mmHg at 25°C
• Refractive Index: 1.659
• Storage Temp.: Refrigerator
• Solubility: Ethyl Acetate; Methanol; DMSO
• CAS DataBase Reference: bis(4-hydroxyphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: bis(4-hydroxyphenyl)acetic acid(40232-93-7)
• EPA Substance Registry System: bis(4-hydroxyphenyl)acetic acid(40232-93-7)

Safety Data

• Hazardous Substances Data: 40232-93-7(Hazardous Substances Data)

Usage

Uses

Bis(4-hydroxyphenyl)acetic Acid is a bis-phenolic derivative formed from O-demethylation and dechlorination of an insecticide, methoxychlor. Also, it is derived from Glyoxylic Acid (G754995), which is used as a reagent in the synthesis of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-L-leucine, a novel nonpeptide chemotype selective for neurotensin receptor 2. Also, used as a reagent in the synthesis of elemonic acid derivatives as Pin 1 inhibitors.

InChI:InChI=1/C14H12O4/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8,13,15-16H,(H,17,18)

Upstream product

• 4541-73-5 2,2-bis-(4-methoxyphenyl)acetic acid 
• 108-95-2 phenol 
• 33646-40-1 4-methoxymandelonitrile 
• 2132-70-9 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene 
• 298-12-4 Glyoxilic acid 
• 101097-05-6 2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)acetonitrile 

Downstream Products

• 103271-60-9 4-Benzyloxyanilid der Bis-(4-acetoxy-phenyl)-essigsaeure 
• 114162-33-3 Bis-glycerylaether des Bis-(4-hydroxyphenyl)-acetanilids 
• 116601-31-1 4-Hydroxy-anilid der Bis-(4-acetoxy-phenyl)-essigsaeure 
• 102664-61-9 Bis-(4-acetoxyphenyl)-acetanilid 
• 102079-03-8 Bis-(4-hydroxyphenyl)-acetanilid 
• 100870-54-0 Bis-<4-hydroxy-phenyl>-essigsaeure-hydrazid 
• 102012-86-2 Bis-(4-acetoxyphenyl)-N-dimethylacetamid 
• 101734-67-2 Bis-(4-acetoxyphenyl)-acetamid 
• 101293-63-4 2,2-bis(4-hydroxyphenyl)-N,N-dimethylacetamide 
• 103758-81-2 Bis-glycerylether des Bis-(4-hydroxyphenyl)-acetomorpholid 
• 102756-92-3 4-[bis-(4-acetoxy-phenyl)-acetyl]-morpholine 
• 109596-97-6 4-[bis-(4-hydroxy-phenyl)-acetyl]-morpholine 
• 102027-72-5 bis-(4-acetoxy-phenyl)-acetyl chloride 
• 94159-41-8 bis(4-hydroxy-3,5-dibromo-phenyl)ethanoic acid 

Relevant articles and documents

methyl-2,2-bis(4-hydroxyphenyl)methyl acetate synthesis method

The present invention relates to the field of production of chemical industry products, particularly to a methyl-2,2-bis(4-hydroxyphenyl)methyl acetate synthesis method. According to the synthesis method, phenol and glyoxylic acid are adopted as main raw materials, and a condensation and esterification two-step process route is performed; in the condensation reaction step, phenol, water and glyoxylic acid are firstly added at a low temperature condition and then concentrated sulfuric acid is added in a dropwise manner, or glyoxylic acid and water are firstly added and then phenol and concentrated sulfuric acid are simultaneously added in a dropwise manner, or phenol and water are firstly added and then glyoxylic acid and concentrated sulfuric acid are simultaneously added in a dropwise manner; and the filter cake obtained through the condensation reaction is added with methanol and concentrated sulfuric acid, a heating reflux esterification reaction is performed, concentration and filtration are performed to obtain a crude product, the crude product is dried, and the dried crude product is subjected to recrystallization purification to obtain the methyl-2,2-bis(4-hydroxyphenyl)methyl acetate. According to the present invention, the extraction with a large amount of the organic solvent is avoided, the operation is simple, the pollution is low, the yield is high, and the synthesis method is suitable for large-scale industrial production.

THE CHEMISTRY OF SOME METHOXYCHLOR DERIVATIVES

The preparation of 1-chloro-2,2-bis(p-methoxyphenyl)ethylene (3a) and of 1-chloro-2,2-bis(p-hydroxyphenyl)ethylene (3b), required for a study of the microbial degradation of methoxychlor (1a) was reinvestigated.The methoxy compound (3a) was readily obtained by alkaline dehydrohalogenation of 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethane (2a), but similar treatment of 1,1-dichloro-2,2-bis(p-hydroxyphenyl)ethane (2b) gave a chlorine-free compound, characterized as the diethyl acetal of 2,2-bis(p-hydroxyphenylacetaldehyde (5a) on the basis of spectroscopic evidence and comparison with a model compound.Also, 2,2-bis(p-methoxyphenyl)acetic acid (4a) and 2,2-bis(p-hydroxyphenyl)acetic acid (4b) were prepared and the solubility and p-values (ethyl acetate / water) of these acids were determined.