4024-30-0

Basic information

• Product Name: 4H-Imidazo[4,5,1-ij]quinoline,2-chloro-5,6-dihydro-(6CI,7CI,8CI,9CI)
• Synonyms: 4H-Imidazo[4,5,1-ij]quinoline,2-chloro-5,6-dihydro-(6CI,7CI,8CI,9CI)
• CAS NO: 4024-30-0
• Molecular Formula: C₁₀H₉ClN₂
• Molecular Weight: 192.64486
• Product Categories: BENZIMIDAZOLE
• Mol File: 4024-30-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4H-Imidazo[4,5,1-ij]quinoline,2-chloro-5,6-dihydro-(6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Imidazo[4,5,1-ij]quinoline,2-chloro-5,6-dihydro-(6CI,7CI,8CI,9CI)(4024-30-0)
• EPA Substance Registry System: 4H-Imidazo[4,5,1-ij]quinoline,2-chloro-5,6-dihydro-(6CI,7CI,8CI,9CI)(4024-30-0)

Safety Data

• Hazardous Substances Data: 4024-30-0(Hazardous Substances Data)

Upstream product

• 4024-28-6 2-oxo-1,2,5,6-tetrahydro-4H-imidazo<4,5,1-ij>quinoline 

Relevant articles and documents

SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS

Disclosed are substituted tricyclic benzimidazoles compounds as defined herein in formula (I) or pharmaceutically acceptable salts thereof. The compounds of the invention selectively inhibit CDK8 and are therefore useful for treating diseases related to this kinase, especially colorectal and melanoma cancers and other solid and hemathological malignancies, autoimmune diseases and inflammatory diseases. Also disclosed are processes for preparing these compounds.

IMIDAZOL-4-YLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

A compound of formula (I): STR1 in which R 1 represents a hydrogen atom or a straight or branched (C 1-C 4) alkyl group; andA represents a 5,6-dihydro-4H-imidazo[4, 5,1-ij] quinol-2-yl group, a 4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-methyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 4-phenylmethyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 5-methyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group, a 5, 6-dihydro-4H-imidazo[1,5,4-de]quinoxalin-2-yl group, a 6-oxo-5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl group, or a 5-methyl-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2-yl group which may be unsubstituted or substituted in the 6-position by a phenylmethyl group; or an addition salt thereof with a pharmaceutically acceptable acid.