40251-61-4

Upstream product

• 40251-62-5 3-chloro-4-trifluoromethoxy-benzoyl fluoride 

Downstream Products

• 129604-26-8 3-chloro-4-(trifluoromethoxy)benzonitrile 
• 851225-03-1 5-(3-chloro-4-trifluoromethoxy-phenyl)-[1,3,4]-oxathiazol-2-one 

Relevant academic research and scientific papers

Antimycotically active substituted 2-aminothiazoles

Antimicotically active 2-aminothiazoles have been found having the formula STR1 in which R1 represents hydrogen or alkyl and R2 represents optionally substituted cyclohexyl or phenyl which is substituted by halogen, alkyl, halogenoalkyl, halogenoalkoxy, dioxyhalogenoalkyl or halogenoalkylthio, and their physiologically tolerable acid addition salts, with the exception of the compounds 4-(4-chlorophenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]thiazole and 4-(2,4-dichlorophenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]-thiazole and 4-(4-chloro-2-methylphenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]-thiazole and with the exception of the physiologically tolerable acid addition salts of these compounds have been found.

Fluorine-containing acetophenones optionally halogenated on the CH3 -group and their precurser fluorine-containing benzonitriles

Fluorine-containing acetophenones, optionally halogenated on the CH3 group, of the formula STR1 in which X represents hydrogen, chlorine or bromine and the radicals R1 to R5 have the following meaning, a) R1 and R4 denote fluorine, R2 and R5 denote chlorine and R3 denotes CF3, or b) R1, R3 and R4 denote fluorine and R2 and R5 denote hydrogen, or c) R1, R4 and R5 denote hydrogen, R2 denotes chlorine and R3 denotes CF3, or d) R1, R4 and R5 denote hydrogen, R2 denotes chlorine and R3 denotes OCF3, or e) R1, R4 and R5 denote hydrogen and R2 and R3 denote CF3, or f) R1 denotes chlorine, R2 denotes CF3 and R3, R4 and R5 denote hydrogen, or g) R1 denotes chlorine, R2, R3 and R4 denote hydrogen and R5 denotes CF3, or h) R1 denotes chlorine, R2, R4 and R5 denote hydrogen and R3 denotes CF3 and a process for their preparation from the corresponding fluorinated benzonitriles or benzyl halides by reaction with an organomagnesium compound capable of introducing methyl groups and subsequent hydrolysis, if appropriate followed by a chlorination or bromination.