40255-47-8

Usage

Use

antidepressant and antipsychotic medication

Pharmacological action

selective antagonist for serotonin 5-HT1A and 5-HT1B receptors

Function

regulates mood and anxiety

Therapeutic potential

treatment of depressive disorders and other psychiatric conditions

Research interest

modulation of neurochemical responses in the brain, neuroscience research

Upstream product

• 75426-49-2 3-[4-(4-methylphenyl)piperazin-1-yl]propanenitrile 
• 763877-21-0 N-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-phthalimide 
• 39593-08-3 (4-methylphenyl)piperazine 

Downstream Products

• 129010-98-6 2-Methoxy-5-sulfamoyl-N-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-benzamide 
• 90619-37-7 2-[3-(4-p-Tolyl-piperazin-1-yl)-propyl]-3a,4,7,7a-tetrahydro-isoindole-1,3-dione; hydrochloride 
• 90619-44-6 1,8,8-Trimethyl-3-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-3-aza-bicyclo[3.2.1]octane-2,4-dione; hydrochloride 
• 1044529-29-4 Z₀₆₆-0019 
• 1240266-75-4 C₂₇H₃₆N₄O*ClH 

Relevant academic research and scientific papers

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

A small molecule library of piperazinylalkylisoxazole derivatives containing about 600 compounds was designed, synthesized and evaluated for blocking effects on T-type Ca2+ channel. Several ligands were identified to possess high inhibitory activity against the T-type Ca 2+ channel. The compound 21 with trifluoromethyl substituents at C3-position of phenyl group (R1) and C2- position of phenyl group (R2) showed the highest inhibitory activity with IC50 value of 1.02μM, which is comparable to that of mibefradil.

POTENTIAL NEUROLEPTICS OF THE ORTHOPRAMIDE SERIES; SYNTHESIS OF N-(3-(TERT.AMINO)PROPYL)-5-SULFAMOYL-2-METHOXYBENZAMIDES

Heating ethyl 5-sulfamoyl-2-methoxybenzoate with a series of twelve 3-(tert.amino)propylamines (IIIa-IIIl) afforded the title compounds IIa-IIl which were transformed to salts and subjected to pharmacological screening as potential neuroleptics of the sulpiride series.Only compounds IId (hydrogen oxalate, VUFB-15 453) and IIg (methanesulfonate, VUFB-15 397) showed indications of the desired psychotropic activity.