75426-49-2

Basic information

• Product Name: 3-[4-(4-methylphenyl)piperazin-1-yl]propanenitrile
• CAS NO: 75426-49-2
• Molecular Formula: C₁₄H₁₉N₃
• Molecular Weight: 229.3208
• Mol File: 75426-49-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 413.4°C at 760 mmHg
• Flash Point: 183.2°C
• Density: 1.059g/cm³
• Vapor Pressure: 4.8E-07mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 3-[4-(4-methylphenyl)piperazin-1-yl]propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(4-methylphenyl)piperazin-1-yl]propanenitrile(75426-49-2)
• EPA Substance Registry System: 3-[4-(4-methylphenyl)piperazin-1-yl]propanenitrile(75426-49-2)

Safety Data

• Hazardous Substances Data: 75426-49-2(Hazardous Substances Data)

Usage

General Description

3-[4-(4-methylphenyl)piperazin-1-yl]propanenitrile is a chemical compound with the molecular formula C17H23N3. It is a piperazine derivative that contains a propanenitrile functional group. 3-[4-(4-methylphenyl)piperazin-1-yl]propanenitrile is commonly used in medicinal chemistry as a starting material for the synthesis of various pharmaceuticals and research chemicals. It has been studied for its potential therapeutic applications in the treatment of various neurological and psychiatric disorders. Additionally, it has been investigated for its activity as a serotonin receptor agonist and has shown potential as a drug candidate for the management of depression and anxiety. 3-[4-(4-methylphenyl)piperazin-1-yl]propanenitrile is also of interest in the field of organic chemistry for its unique chemical structure and reactivity.

Upstream product

• 39593-08-3 (4-methylphenyl)piperazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 61015-49-4 3-(4-p-tolyl-piperazin-1-yl)-propionamide 
• 500294-65-5 3-[4-(4-methylphenyl)piperazin-1-yl]propanoic acid 
• 129010-98-6 2-Methoxy-5-sulfamoyl-N-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-benzamide 
• 90619-44-6 1,8,8-Trimethyl-3-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-3-aza-bicyclo[3.2.1]octane-2,4-dione; hydrochloride 
• 90619-37-7 2-[3-(4-p-Tolyl-piperazin-1-yl)-propyl]-3a,4,7,7a-tetrahydro-isoindole-1,3-dione; hydrochloride 
• 40255-47-8 3-(4-(4-methylphenyl)-1-piperazinyl)propylamine 

Relevant articles and documents

Cu-nanoparticles: A chemoselective catalyst for the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile

A novel method for effecting the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile using Cu-nanoparticles is described. The method features the use of 10 mol % Cu (14-17 nm) nanoparticles under mild reaction conditions to afford the addition products in good to excellent yields. The Cu-nanoparticles selectively catalysed the aza-Michael reaction of N-alkyl- and N-arylpiperazines in the presence of aromatic amino or aliphatic hydroxy groups.

Synthesis and pharmacology of 1-(4-aryl-1-piperazinyl-alkyl)-4-(4-methoxyphenyl) piperidine-2,6-diones: Tranquilizers

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