402578-38-5Relevant articles and documents
A convenient route to α-amino acids with β-alkyne substituents from a serine derived aziridine
Turner, John J,Leeuwenburgh, Michiel A,Van Der Marel, Gijs A,Van Boom, Jacques H
, p. 8713 - 8716 (2001)
1-[(S)-1-(2-Nitrobenzenesulfonyl)-aziridin-2-yl]-4-methyl-2,6,7- trioxabicyclo[2.2.2]octane 5 was ring opened regioselectively with a variety of lithium acetylides to give α-amino acids bearing γ,δ-unsaturation in very good to excellent yields. The 2-nitrobenzenesulfonyl and OBO ester protecting groups were removed in excellent overall yield.