402578-78-3

Basic information

• Product Name: N-[(S)-1-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-4-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-but-3-ynyl]-2-nitro-benzenesulfonamide
• Synonyms: N-[(S)-1-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-4-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-but-3-ynyl]-2-nitro-benzenesulfonamide
• CAS NO: 402578-78-3
• Molecular Weight: 905.035
• Mol File: 402578-78-3.mol

Chemical Properties

• CAS DataBase Reference: N-[(S)-1-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-4-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-but-3-ynyl]-2-nitro-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(S)-1-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-4-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-but-3-ynyl]-2-nitro-benzenesulfonamide(402578-78-3)
• EPA Substance Registry System: N-[(S)-1-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-4-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-but-3-ynyl]-2-nitro-benzenesulfonamide(402578-78-3)

Safety Data

• Hazardous Substances Data: 402578-78-3(Hazardous Substances Data)

Upstream product

• 402578-38-5 (S)-3-Hydroxy-2-(2-nitro-benzenesulfonylamino)-propionic acid 3-methyl-oxetan-3-ylmethyl ester 
• 402578-43-2 N-[2-hydroxy-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-2-nitro-benzenesulfonamide 
• 99314-44-0 (3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate 
• 402578-49-8 1-[(S)-1-(2-nitrobenzenesulfonyl)-aziridin-2-yl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 

Downstream Products

• 402578-87-4 (S)-2-tert-Butoxycarbonylamino-5-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-pent-4-ynoic acid 
• 402578-84-1 (S)-2-Amino-5-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-pent-4-ynoic acid 
• 213828-80-9 6,10-anhydro-7,8,9,11-tetra-O-benzyl-2,3,4,5-tetradeoxy-2-(tert-butoxycarbonylamino)-D-threo-L-galacto-undeconic acid 
• 402578-82-9 (S)-1-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-4-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-but-3-ynylamine 

Relevant articles and documents

A convenient route to α-amino acids with β-alkyne substituents from a serine derived aziridine

1-[(S)-1-(2-Nitrobenzenesulfonyl)-aziridin-2-yl]-4-methyl-2,6,7- trioxabicyclo[2.2.2]octane 5 was ring opened regioselectively with a variety of lithium acetylides to give α-amino acids bearing γ,δ-unsaturation in very good to excellent yields. The 2-nitrobenzenesulfonyl and OBO ester protecting groups were removed in excellent overall yield.