402717-66-2

Basic information

• Product Name: 1-benzoyl-N-4-methylbenzenesulfonyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 1-benzoyl-N-4-methylbenzenesulfonyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 402717-66-2
• Molecular Weight: 391.491
• Mol File: 402717-66-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-benzoyl-N-4-methylbenzenesulfonyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzoyl-N-4-methylbenzenesulfonyl-1,2,3,4-tetrahydroisoquinoline(402717-66-2)
• EPA Substance Registry System: 1-benzoyl-N-4-methylbenzenesulfonyl-1,2,3,4-tetrahydroisoquinoline(402717-66-2)

Safety Data

• Hazardous Substances Data: 402717-66-2(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 64-04-0 phenethylamine 
• 1074-12-0 phenylglyoxal hydrate 
• 5450-75-9 4-methyl-N-(2-phenylethyl)benzenesulfonamide 
• 16222-10-9 1-phenyl-2-(phenylthio)ethanone 

Downstream Products

• 1372409-85-2 1-benzoyl-N-4-methylbenzenesulfonyl-1,2,3,4-tetrahydroisoquinoline thiosemicarbazone 
• 16576-23-1 1-benzoylisoquinoline 
• 63023-79-0 1-benzoyl-3,4-dihydroisoquinoline 

Relevant articles and documents

Synthesis and cytotoxicity of novel N-sulfonyl-1,2,3,4- tetrahydroisoquinoline thiosemicarbazone derivatives

The modified Pictet-Spengler reaction of phenylethylbenzene sulfonamide with a commercially available glyoxal to construct 1-benzoyl- and 1-acetyl-1,2,3,4-tetrahydroisoquinolines 9a-n has been reported. The reaction could be accomplished, regardless of th

Elaboration of 1-benzoyltetrahydroisoquinoline derivatives employing a Pictet-Spengler cyclization with α-chloro-α-phenylthioketones. Synthesis of O-methylvelucryptine

The reaction of N-tosyl-β-phenethylamines with α-chloro-α-phenylthioketones, leading to 1-benzoyl- and 1-pivaloyl-tetrahydroisoquinolines under modified Pictet-Spengler conditions, is described. The synthesis of O-methylvelucryptine employing this transformation as a key step is reported.