5450-75-9

Basic information

• Product Name: NSC15155
• Synonyms: NSC15155;N-(2-Phenylethyl)-p-toluenesulfonamide;N-Phenethyl-4-methylbenzenesulfonamide;4-Methyl-N-(2-phenylethyl)benzenesulfonaMide, 97%
• CAS NO: 5450-75-9
• Molecular Formula: C₁₅H₁₇NO₂S
• Molecular Weight: 275.366
• Mol File: 5450-75-9.mol
• Article Data: 48

Chemical Properties

• Boiling Point: 432.4 °C at 760 mmHg
• Flash Point: 215.3 °C
• Appearance: /
• Density: 1.179 g/cm³
• Vapor Pressure: 1.11E-07mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: NSC15155(CAS DataBase Reference)
• NIST Chemistry Reference: NSC15155(5450-75-9)
• EPA Substance Registry System: NSC15155(5450-75-9)

Safety Data

• Hazardous Substances Data: 5450-75-9(Hazardous Substances Data)

Usage

General Description

NSC15155, also known as 4-Methylumbelliferone (4-MU) or hymecromone, is a natural coumarin derivative found in certain plants and fruits. It has been studied for its potential therapeutic effects, including anti-inflammatory, antifibrotic, and anti-cancer properties. NSC15155 has been shown to inhibit the synthesis of hyaluronic acid, a component of the extracellular matrix that is associated with inflammation and fibrosis. Additionally, NSC15155 has demonstrated anti-cancer effects in various in vitro and in vivo studies, with potential applications in cancer treatment. As a result, NSC15155 is being actively researched for its potential medicinal uses, particularly in the treatment of inflammatory diseases and cancer.

InChI:InChI=1/C15H17NO2S/c1-13-7-9-15(10-8-13)19(17,18)16-12-11-14-5-3-2-4-6-14/h2-10,16H,11-12H2,1H3

Upstream product

• 67-56-1 methanol 
• 24395-14-0 N-(p-tolylsulfonyl)-2-phenylaziridine 
• 100-42-5 styrene 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 70-55-3 toluene-4-sulfonamide 
• 884866-01-7 1-(4-methylbenzensulfonyl)-4-phenyl-1H-1,2,3-triazole 
• 1413940-99-4 N-(2-phenylethyl)-N-(1,1-dimethylallyloxy)carbonyl-p-toluenesulfonamide 
• 92273-73-9 n-butylzinc bromide 
• 101-97-3 Ethyl 2-phenylethanoate 
• 60-12-8 2-phenylethanol 
• 17798-13-9 N-(2-chloro-2-phenylethyl)tosylamide 
• 103-63-9 1-phenyl-2-bromoethane 
• 140-29-4 phenylacetonitrile 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 159690-31-0 1-p-Toluolsulfonyl-1-phenethyl-hydrazin 
• 1635-09-2 N-dodecyl-4-methylbenzenesulfonamide 
• 18049-99-5 N-hexadecyl-p-toluenesulfonamide 
• 1950-69-2 toluene-p-sulfonyl bromide 
• 622-24-2 2-phenylethyl chloride 
• 103-63-9 1-phenyl-2-bromoethane 
• 141666-91-3 N-[2-(4-chlorophenyl)ethyl]-4-methylbenzenesulfonamide 
• 141666-92-4 4-methyl-N-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide 
• 141666-87-7 1-Tosyl-1-<2-(4-methoxyphenyl)ethyl>hydrazine 
• 146404-41-3 C₁₅H₁₇ClN₂O₂S 
• 146404-40-2 1-tosyl-1-hexadecylhydrazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 151259-26-6 C₁₉H₃₄N₂O₂S 
• 39830-55-2 1-[(4-methylphenyl)sulfonyl]indoline 

Relevant articles and documents

Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway

Both ruthenium (Ru) and isoquinoline (IQ) compounds are regarded as potential anticancer drug candidates. Here, we report the synthesis and characterization of three novel cyclometalated Ru(II)-isoquinoline complexes: RuIQ-3, RuIQ-4, and RuIQ-5, and evalu

N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls

The photochemical fragmentation of N-aroylsulfonamides 9 (ASAP) is a powerful method for the preparation of various biaryls. Compounds 9 are easily accessible in two steps from amines by treatment with arenesulfonyl chlorides and aroyl chlorides. Many of these compounds were prepared for the first time. The irradiation takes place in a previously developed continuous-flow reactor using inexpensive UVB or UVC fluorescent lamps. Isocyanates and sulphur dioxide are formed as the only by-products. The ASAP tolerates a variety of functional groups and is even suited for the preparation of phenylnaphthalenes and terphenyls. The ASAP mechanism was elucidated by interaction of photophysical and quantum chemical (DFT) methods and revealed a spirocyclic biradical as key intermediate.

Catalyst-Free Visible-Light-Mediated Iodoamination of Olefins and Synthetic Applications

Herein we report a catalyst- and metal-free visible-light-mediated protocol enabling the iodoamination of miscellaneous olefins. This protocol is characterized by high yields under environmentally benign reaction conditions utilizing commercially available substrates and a green and biodegradable solvent. Furthermore, the protocol allows for late-stage functionalization of bioactive molecules and can be scaled to gram quantities of product, which offers manifold possibilities for further transformations, including morpholine, piperidine, pyrrolidine, and aziridine synthesis.