402717-72-0

Upstream product

• 14165-67-4 N-(3,4-dimethoxyphenethyl)-4-methylbenzenesulfonamide 
• 402717-71-9 2-chloro-1-(4-methoxy-phenyl)-2-phenylsulfanyl-ethanone 
• 21875-72-9 1-(4-methoxy-phenyl)-2-phenylsulfanyl-ethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 17052-80-1 (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(4-methoxyphenyl)-methanone 

Relevant academic research and scientific papers

New syntheses of 1-benzoyltetrahydroisoquinoline derivatives using polymer-supported bis(trifluoroacetoxyiodo)benzene

The reaction of N-benzenesulfonyl-β-phenethylamines with α-benzoyl sulfides using polymer-supported bis(trifluoroacetoxyiodo) benzene (PSBTI) gives moderate to good yields of the corresponding 1-benzoyltetrahydroisoquinoline derivatives.

Elaboration of 1-benzoyltetrahydroisoquinoline derivatives employing a Pictet-Spengler cyclization with α-chloro-α-phenylthioketones. Synthesis of O-methylvelucryptine

The reaction of N-tosyl-β-phenethylamines with α-chloro-α-phenylthioketones, leading to 1-benzoyl- and 1-pivaloyl-tetrahydroisoquinolines under modified Pictet-Spengler conditions, is described. The synthesis of O-methylvelucryptine employing this transformation as a key step is reported.