402717-71-9

Upstream product

• 21875-72-9 1-(4-methoxy-phenyl)-2-phenylsulfanyl-ethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 108-98-5 thiophenol 

Downstream Products

• 17052-80-1 (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(4-methoxyphenyl)-methanone 
• 17656-61-0 (6,7-methylenedioxyisoquinolinyl)-(4'-methoxyphenyl)-methanone 
• 402717-72-0 1-(p-methoxybenzoyl)-6,7-dimethoxy-2-(p-tosyl)-1,2,3,4-tetrahydroisoquinoline 
• 471908-70-0 (4-methoxy-phenyl)-[6-(toluene-4-sulfonyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-methanone 

Relevant academic research and scientific papers

Elaboration of 1-benzoyltetrahydroisoquinoline derivatives employing a Pictet-Spengler cyclization with α-chloro-α-phenylthioketones. Synthesis of O-methylvelucryptine

The reaction of N-tosyl-β-phenethylamines with α-chloro-α-phenylthioketones, leading to 1-benzoyl- and 1-pivaloyl-tetrahydroisoquinolines under modified Pictet-Spengler conditions, is described. The synthesis of O-methylvelucryptine employing this transformation as a key step is reported.