402731-95-7

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 326473-57-8 (E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine 

Downstream Products

• 326473-66-9 (2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester 
• 326473-67-0 (R)-2-{(2E,7E)-(5S,6R)-5-[(S)-2-(3-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-6-methyl-8-phenyl-octa-2,7-dienoylamino}-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester 

Relevant academic research and scientific papers

Synthesis of amide analogs of arenastatin A

In order to probe the metabolism of arenastatin A, a potent cytotoxic depsipeptide from the marine sponge Dysidea arenaria, we synthesized three analogs in which the ester linkages were replaced by amide bonds. Triamide analog-II and tetraamide analog, both of which contained a 15,20-amide linkage, showed stability in serum. However, arenastatin A and triamide analog-I, which both contained a 15,20-ester moiety, were readily metabolized in serum. Among the three amide analogs, only triamide analog-II exhibited potent cytotoxic activity against KB cells. (C) 2000 Elsevier Science Ltd.