402822-75-7

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 675578-39-9 N-allyl-N-p-toluenesulfonyl-2-formyl-4,5,6-trimethoxyaniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 61948-85-4 3,4,5-trimethoxyanthranilic acid 
• 675578-36-6 N-p-toluenesulfonyl-3,4,5-trimethoxyanthranilic acid methyl ester 
• 675578-37-7 N-p-toluenesulfonyl-2-hydroxymethyl-4,5,6-trimethoxyaniline 
• 675578-38-8 N-p-toluenesulfonyl-2-formyl-4,5,6-trimethoxyaniline 
• 5035-82-5 methyl 3,4,5-trimethoxyanthranilate 
• 19493-09-5 Methylenetriphenylphosphorane 

Relevant academic research and scientific papers

A novel synthesis of substituted quinolines using ring-closing metathesis (RCM): Its application to the synthesis of key intermediates for anti-malarial agents

A method for synthesizing substituted quinolines using ruthenium-catalyzed ring-closing metathesis as a key step has been developed. Substituted 1,2-dihydroquinolines, 4-silyloxy-1,2-dihydroquinoline and 4-methoxy-1,2- dihydroquinoline, were successfully synthesized in excellent yields via ene-ene metathesis and silyl or alkyl enol ether-ene metathesis, respectively. The synthetic intermediates of the antimalarial agents quinine, chloroquine, and PPMP-quinine hybrid were efficiently synthesized by this methodology.

Synthesis of substituted 1,2-dihydroquinolines and quinolines using ene-ene metathesis and ene-enol ether metathesis

We describe a novel and convenient method for quinoline synthesis using ring-closing olefin metathesis (RCM), ene-ene metathesis, and ene-enol ether metathesis. We also report the first example of enol silyl ether-ene metathesis to produce cyclic enol silyl ether. Using this method, versatile substituted quinoline derivatives were readily prepared in excellent yield from anthranilic acid derivatives.