5035-82-5

Basic information

• Product Name: Methyl 2-amino-3,4,5-trimethoxybenzoate
• Synonyms: TIMTEC-BB SBB000807;3,4,5-TRIMETHOXYANTHRANILIC ACID METHYL ESTER;METHYL 2-AMINO-3,4,5-TRIMETHOXYBENZOATE;METHYL 3,4,5-TRIMETHOXYANTHRANILATE;2-Amino-3,4,5-trimethoxybenzoic acid methyl ester;Einecs 225-728-8;Anthranilic acid, 3,4,5-trimethoxy-, methyl ester;Benzoic acid, 2-amino-3,4,5-trimethoxy-, methyl ester
• CAS NO: 5035-82-5
• Molecular Formula: C₁₁H₁₅NO₅
• Molecular Weight: 241.24
• EINECS: 225-728-8
• Product Categories: Aromatic Esters;C10 to C11;Carbonyl Compounds;Esters
• Mol File: 5035-82-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 44-45 °C(lit.)
• Boiling Point: 127-140 °C0.1 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.2611 (rough estimate)
• Vapor Pressure: 2.06E-12mmHg at 25°C
• Refractive Index: 1.5080 (estimate)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 2.62±0.10(Predicted)
• CAS DataBase Reference: Methyl 2-amino-3,4,5-trimethoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-amino-3,4,5-trimethoxybenzoate(5035-82-5)
• EPA Substance Registry System: Methyl 2-amino-3,4,5-trimethoxybenzoate(5035-82-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5035-82-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 5035-82-5 differently. You can refer to the following data:
1. Methyl 2-Amino-3,4,5-trimethoxybenzoate could be a constituent contributing to the aroma of green tea leaves.
2. Methyl 3,4,5-trimethoxyanthranilate may be used in chemical synthesis.

InChI:InChI=1/C21H22BrN3O/c1-14-6-9-16(10-7-14)25-21-17(5-3-4-12-23-21)20(24-25)18-13-15(22)8-11-19(18)26-2/h6-11,13,24H,3-5,12H2,1-2H3

Upstream product

• 61948-85-4 3,4,5-trimethoxyanthranilic acid 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 118-41-2 Eudesmic acid 
• 23346-82-9 2-bromo-3,4,5-trimethoxybenzoic acid 
• 77-76-9 2,2-dimethoxy-propane 
• 186581-53-3 diazomethane 
• 5081-42-5 3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester 

Downstream Products

• 61948-85-4 3,4,5-trimethoxyanthranilic acid 
• 81469-78-5 N-(o-Nitrobenzoyl-3,4,5-trimethoxy)anthranilic acid methyl ester 
• 102178-49-4 2-Phenylacetamino-3,4,5-trimethoxy-benzoesaeure-methylester 
• 3872-84-2 2-Trifluoracetamino-3,4,5-trimethoxy-benzoesaeure-methylester 
• 675578-36-6 N-p-toluenesulfonyl-3,4,5-trimethoxyanthranilic acid methyl ester 
• 192863-64-2 2-chloro-3,4,5-trimethoxybenzoic acid methyl ester 
• 214476-46-7 4-hydroxy-6,7,8-trimethoxy-quinoline-3-carbonitrile 
• 5081-28-7 2-Amino-3,4,5-trimethoxy-benzoesaeure-methylamid 
• 5081-26-5 2-Chloracetylamino-3,4,5-trimethoxy-benzoesaeure-methylester 
• 35241-34-0 2-(4-Chlorophenyl)-4-hydroxy-6,7,8-trimethoxyquinazoline 
• 16064-19-0 6,7,8-Trimethoxy-4(3H)-quinazolinone 
• 33371-00-5 4-chloro-6,7,8-trimethoxy-quinazoline 
• 1488139-63-4 6,7,8-trimethoxy-2-phenyl-4H-benzo[d] [1,3]oxazin-4-one 
• 1488139-85-0 2-benzamido-3,4,5-trihydroxy-N-(3-phenylpropyl) benzamide 

Relevant articles and documents

PDIA4 INHIBITORS AND USE THEREOF FOR INHIBITING ?-CELL PATHOGENESIS AND TREATING DIABETES

Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.

Synthesis of substituted 1,2-dihydroquinolines and quinolines using ene-ene metathesis and ene-enol ether metathesis

We describe a novel and convenient method for quinoline synthesis using ring-closing olefin metathesis (RCM), ene-ene metathesis, and ene-enol ether metathesis. We also report the first example of enol silyl ether-ene metathesis to produce cyclic enol silyl ether. Using this method, versatile substituted quinoline derivatives were readily prepared in excellent yield from anthranilic acid derivatives.

2-(Piperazinyl)-4-pyrimioinamines

Herein is disclosed 2-(1-piperazinyl)-4-pyrimidinamine derivatives, acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives. The derivatives are distinguished most readily by having novel substituents at position 4 of the piperazinyl radical, the substituents being selected from the group consisting of optionally substituted 2-cycloheptimidazolyl, 1,4,5,6,7,8-hexahydrocycloheptimidazol-2-yl, 2-benzoxazolyl, benzthiazol-2-yl, 1H-2-benzimidazolyl and 1-oxo-2,4,6-cycloheptarien-2-yl. The derivatives are useful for treating hypertension in a mammal.