402823-61-4Relevant academic research and scientific papers
Revision of the structure of haliclorensin to (S)-7-methyl-1,5-diazacyclotetradecane and confirmation of the new structure by synthesis
Heinrich, Markus R,Kashman, Yoel,Spiteller, Peter,Steglich, Wolfgang
, p. 9973 - 9978 (2001)
A reinvestigation of the marine alkaloid haliclorensin led to a revision of the proposed structure to 7-methyl-1,5-diazacyclotetradecane. The new structure was confirmed by total synthesis of both optical forms. According to chiroptical measurements and G
Nosyl (2-Nitrobenzenesulfonyl) Annulation Strategy toward Winding Vine-Shaped Bithiophenes
Ashida, Shiomi,Tanaka, Naoki,Ito, Yukiko,Matsuoka, Mitsuru,Hashimoto, Takayoshi,Okano, Kentaro,Miyazaki, Yuji,Kobayashi, Tohru,Yaita, Tsuyoshi,Mori, Atsunori
supporting information, p. 14797 - 14801 (2018/12/11)
Winding vine-shaped bithiophene was synthesized through the nosyl (2-nitrobenzenesulfonyl) cyclization protocol. The reaction of bithiophene bearing bromomethyl groups at the 3,3′-positions with nosylated 1,2-ethylenediamine in the presence of potassium carbonate afforded the annulated product in excellent yield. The obtained bithiophene was found to contain a 10-membered ring, which was confirmed by X-ray analysis. The related nosyldiamine bearing a tri- or tetramethylene group also reacted in a similar manner, affording an 11- or 12-membered macrocycle, respectively.
