402830-01-7

Basic information

• Product Name: ISOVALERYL-L-TYROSYL-L-VALYL-DL-TYROSINAL
• Synonyms: ISOVALERYL-L-TYROSYL-L-VALYL-DL-TYROSINAL;TYROPEPTIN A
• CAS NO: 402830-01-7
• Molecular Formula: C₂₈H₃₇N₃O₆
• Molecular Weight: 511.61
• Product Categories: peptides
• Mol File: 402830-01-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ISOVALERYL-L-TYROSYL-L-VALYL-DL-TYROSINAL(CAS DataBase Reference)
• NIST Chemistry Reference: ISOVALERYL-L-TYROSYL-L-VALYL-DL-TYROSINAL(402830-01-7)
• EPA Substance Registry System: ISOVALERYL-L-TYROSYL-L-VALYL-DL-TYROSINAL(402830-01-7)

Safety Data

• Hazardous Substances Data: 402830-01-7(Hazardous Substances Data)

Upstream product

• 402832-93-3 [(S)-1-{(S)-1-[(S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 402832-94-4 N-[(S)-1-{(S)-1-[(S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethyl]-3-methyl-butyramide 
• 402832-92-2 {(S)-1-[(S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid tert-butyl ester 
• 402832-91-1 [1-benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 1026423-88-0 (S)-1-Benzyloxymethyl-2-(4-benzyloxy-phenyl)-ethylamine 
• 83345-46-4 N-(tert-butyloxycarbonyl)-L-tyrosinol 
• 87745-27-5 (S)-tyrosinol hydrochloride 
• 13734-41-3 t-Boc-L-valine 
• 402832-83-1 isovaleryl-L-tyrosyl-L-valyl-L-tyrosinol 

Downstream Products

• 402832-83-1 isovaleryl-L-tyrosyl-L-valyl-L-tyrosinol 
• 402832-84-2 isovaleryl-L-tyrosyl-L-valyl-D-tyrosinol 
• 5034-68-4 4-[(2S)-2-amino-3-hydroxypropyl]phenol 
• 58889-64-8 (R)-4-(2-amino-3-hydroxypropyl)phenol 

Relevant articles and documents

Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2 II. Structure determination and synthesis

The structures of tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2, were determined by analysis of various NMR experiments. The 1H and 13C NMR of tyropeptins were complicated due to the presence of an aldehyde group. Therefore, tyropeptins were converted to their alcohols by sodium borohydride. These alcohol derivatives gave assignable NMR spectra. The stereochemistry of tyropeptins were determined by analysis of acid hydrolysis products from tyropeptins, and further confirmed by the total synthesis. The structures of tyropeptins A and B were found to be isovaleryl-L-tyrosyl-L-valyl-DL-tyrosinal and n-butyryl-L-tyrosyl-L-leucyl-DL-tyrosinal, respectively.