83345-46-4

Basic information

• Product Name: Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester
• Synonyms: Carbamicacid, [(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester (9CI); Carbamic acid, [2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-,1,1-dimethylethyl ester, (S)-;(S)-[1-(Hydroxymethyl)-2-(4-hydroxyphenyl)ethyl]carbamic acid tert-butyl ester;[(1S)-1-Hydroxymethyl-2-(4-hydroxyphenyl)ethyl]carbamic acid tert-butyl ester;tert-Butyl [(S)-2-hydroxy-1-(4-hydroxybenzyl)ethyl]carbamate
• CAS NO: 83345-46-4
• Molecular Formula: C14H21 N O4
• Molecular Weight: 267.325
• Mol File: 83345-46-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester(83345-46-4)
• EPA Substance Registry System: Carbamicacid, N-[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, 1,1-dimethylethylester(83345-46-4)

Safety Data

• Hazardous Substances Data: 83345-46-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 40829-04-7 4-((S)-2-amino-3-hydroxy-propyl)-phenol hydrochloride 
• 1080-06-4 L-Tyr-OMe 
• 16870-43-2 L-tyrosine hydrochloride 
• 5034-68-4 4-[(2S)-2-amino-3-hydroxypropyl]phenol 
• 60-18-4 L-tyrosine 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 87745-27-5 (S)-tyrosinol hydrochloride 
• 40472-66-0 tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 3978-80-1 Boc-Tyr-OH 

Downstream Products

• 1068142-16-4 (S)-2-(tert-butoxycarbonylamino)-3-[4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecoxy) phenyl]-1-propanol 
• 1423401-50-6 (-)-4-[4-{2-hydroxy-1-(4-hydroxybenzyl)ethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene 
• 360577-92-0 N-(tert-butyloxycarbonyl)-3-bromo-L-tyrosinol 
• 66605-58-1 O-benzyl N-Boc-L-tyrosinol 
• 1068142-17-5 (S)-3-[4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecoxy)phenyl]-2-(methanesulfonylamino)propyl methanesulfonate 
• 1068142-14-2 (S)-N-{3-[4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecoxy)phenyl]-2-(methanesulfonylamino)propyl}-4-toluenesulfonamide 
• 1068142-18-6 (S)-N-{1-azido-3-[4-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyloxy)phenyl]prop-2-yl} methanesulfonamide 

Relevant articles and documents

N-[4-phenyl-3-(benzoylamino)-1,1,1-trifluoro-butyl-2-yl]-phenylalaninol derivative as well as preparation method and application thereof

The present invention discloses an N-[4-phenyl-3-(benzoylamino)-1,1,1-trifluoro-butyl-2-yl]-phenylalaninol derivative, which is a compound represented by a general formula I and a pharmaceutically acceptable salt or hydrate thereof, and wherein R1 and R3

ORALLY ADMINISTRABLE VIRIDIOFUNGIN DERIVATIVE HAVING ANTI-HCV ACTIVITY

An object of the present invention is to provide a compound that is useful as an orally available anti-HCV agent. The present invention relates to a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. This compound has an anti-HCV activity and is useful as a medicine.

Two modes of asymmetric polymerization of phenylacetylenes having an L -amino alcohol residue and two hydroxy groups

Four novel chiral phenylacetylenes having an L-amino alcohol residue and two hydroxymethyl groups were synthesized and polymerized by an achiral catalyst ((nbd)Rh+[η6-(C6H5)B -(C6H5)3]) or a chiral catalytic system ([Rh(nbd)Cl]2/(S)- or (R)-phenylethylamine ((S)- or (R)-PEA)). The two resulting polymers having an L-valinol or L-phenylalaninol residue showed Cotton effects at wavelengths around 430 nm. This observation indicated that they had an excess of one-handed helical backbones. Positive and negative Cotton effects were observed only for the polymers having an L-valinol residue produced by using (R)- and (S)-PEA as a cocatalyst, respectively, although the monomer had the same chirality. Even when the achiral catalyst was used, the two resulting polymers having an L-valinol or L-phenylalaninol residue showed Cotton effects despite the long distance between the chiral groups and the main chain. We have found the first example of a new type of chiral monomer, that is, a chiral phenylacetylene monomer having an L-amino alcohol residue and two hydroxy groups that was suitable for both modes of asymmetric polymerization, that is, the helix-sense-selective polymerization (HSSP) with the chiral catalytic system and the asymmetric-induced polymerization (AIP) with the achiral catalyst. The other two monomers having L-alaninol and L-tyrosinol were found to be unsuitable to neither HSSP nor AIP because of their polymers' low solubility.