402925-00-2Relevant academic research and scientific papers
Selective protein tyrosine phosphatatase inhibitors
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, (2008/06/13)
Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
Potent, selective inhibitors of protein tyrosine phosphatase 1B
Xin, Zhili,Oost, Thorsten K.,Abad-Zapatero, Cele,Hajduk, Philip J.,Pei, Zhonghua,Szczepankiewicz, Bruce G.,Hutchins, Charles W.,Ballaron, Steve J.,Stashko, Mike A.,Lubben, Tom,Trevillyan, James M.,Jirousek, Mike R.,Liu, Gang
, p. 1887 - 1890 (2007/10/03)
We have previously reported a novel series of oxalyl-aryl-amino benzoic acid-based, catalytic site-directed, competitive, reversible protein tyrosine phosphatase 1B (PTP1B) inhibitors. With readily access to key intermediates, we utilized a solution phase
Amino (oxo) acetic acid protein tyrosine phosphatase inhibitors
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, (2008/06/13)
Compounds of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Selective protein tyrosine phosphatatase inhibitors
-
, (2008/06/13)
Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
