402933-56-6Relevant articles and documents
Synthesis and structure–activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation
Kroth, Heiko,Sreenivasachary, Nampally,Hamel, Anne,Benderitter, Pascal,Varisco, Yvan,Giriens, Valérie,Paganetti, Paolo,Froestl, Wolfgang,Pfeifer, Andrea,Muhs, Andreas
supporting information, p. 3330 - 3335 (2016/07/12)
It is assumed that amyloid-β aggregation is a crucial event in the pathogenesis of Alzheimer's disease. Novel 2,6-disubstituted pyridine derivatives were designed to interact with the β-sheet conformation of Aβ via donor–acceptor–donor hydrogen bond forma
Gem-substituted αvβ3 antagonists
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, (2008/06/13)
The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αVβ3and/or the αVβ5integrin.