408365-87-7

Usage

Uses

Used in Organic Chemistry:
(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure, including the pyridine and ethyl ester moieties, allows for its potential use in the development of new chemical reactions and the formation of complex molecules.
Used in Medicinal Chemistry:
(6-TERT-BUTOXYCARBONYLAMINO-PYRIDIN-2-YL)-ACETIC ACID ETHYL ESTER is used as a potential pharmaceutical candidate for the development of new drugs. Its structure suggests that it may have properties that could be harnessed for therapeutic applications, such as binding to specific biological targets or modulating certain biological pathways. Further research is required to explore its potential in this field and to evaluate its safety and efficacy.

Upstream product

• 90101-22-7 2-(tert-butoxycarbonylamino)-6-picoline 
• 105-58-8 Diethyl carbonate 
• 1824-81-3 2-Amino-6-methylpyridine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 71469-82-4 ethyl 2-(6-amino-pyridin-2-yl)acetate 
• 402933-56-6 [6-(2-hydroxyethyl)-2-pyridinyl]carbamic acid,1,1-dimethylethyl ester 
• 582308-70-1 2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(5-chloro-2-[1,2,4]triazol-1-yl-benzyl)-acetamide 
• 582308-68-7 2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(5-chloro-2-tetrazol-1-yl-benzyl)-acetamide 
• 582308-66-5 2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(2-aminomethyl-5-chloro-benzyl)-acetamide 

Relevant academic research and scientific papers

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS

Compounds of formula (Ι') that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1)

The invention relates to sulfonamide compounds of formula (I) wherein A, B, R1and X1 to X3 have the meaning as cited in the description and the claims. For example A is biphenyl, B is 2-morpholin-4-yl-2-oxo-ethyl, R1 is H and X1 to X3 are CH. Said compounds are useful as 11β-HSD1 inhibitors. The invention also relates to the preparation of such compounds as well as the production and use as medicament.

P2 pyridine N-oxide thrombin inhibitors: A novel peptidomimetic scaffold

In this study, we have demonstrated that the critical hydrogen bonding motif of the established 3-aminopyrazinone thrombin inhibitors can be effectively mimicked by a 2-aminopyridine N-oxide. As this peptidomimetic core is more resistant toward oxidative metabolism, it also overcomes the metabolic liability associated with the pyrazinones. An optimization study of the P 1 benzylamide delivered the potent thrombin inhibitor 21 (K i = 3.2 nM, 2xaPTT = 360 nM), which exhibited good plasma levels and half-life after oral dosing in the dog (Cmax = 2.6 μM, t 1/2 = 4.5 h).