402948-40-7

Upstream product

• 30379-58-9 benzyl glycolate 
• 67670-69-3 N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester 
• 155155-64-9 (4S,5R,6R)-4-Acetoxy-5-acetylamino-2-phenylsulfanyl-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester 

Downstream Products

• 402948-39-4 methyl {2-benzyl-5-glycolylamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-O_glycolyl-[methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosyl)onate]-α-D-glycero-D-galacto-2-nonulopyranosid}onate 

Relevant academic research and scientific papers

Synthesis of a sialic acid dimer derivative, 2′α-O-benzyl Neu5Ac-α-(2→5)Neu5Gc

The preparation of a disaccharide 2, Neu5Ac-α-(2→5)Neu5Gc having a α-benzyl protecting group at the reducing end, by the coupling of the easily accessible building units 4 and 5 is described. Subsequent deprotection of the coupling adduct led to the isolation of the target compound 2 in high yield.

Synthesis of substrates for the characterisation of sialate-O- acetyltransferases

The synthesis of a series of α-and β-configured sialosides using a Koenigs-Knorr methodology is described. The target compounds can serve as substrates for the investigation of biologically relevant sialate-O- acetyltransferase activity.