402956-36-9Relevant academic research and scientific papers
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
Charoenpattarapreeda, Jiraborrirak,Tan, Yaw Sing,Iegre, Jessica,Walsh, Stephen J.,Fowler, Elaine,Eapen, Rohan S.,Wu, Yuteng,Sore, Hannah F.,Verma, Chandra S.,Itzhaki, Laura,Spring, David R.
, p. 7914 - 7917 (2019)
Herein, we describe the development of a novel staple with an electrophilic warhead to enable the generation of stapled peptide covalent inhibitors of the p53-MDM2 protein-protein interaction (PPI). The peptide developed showed complete and selective covalent binding resulting in potent inhibition of p53-MDM2 PPI.
Solid-Phase Synthesis of Sequence-Defined Informational Oligomers
Strom, Kyle R.,Szostak, Jack W.
, p. 13929 - 13938 (2020/11/20)
Genetic biopolymers utilize defined sequences and monomer-specific molecular recognition to store and transfer information. Synthetic polymers that mimic these attributes using reversible covalent chemistry for base-pairing pose unique synthetic challenge
Photophysical and computational investigations of bis(phosphine) organoplatinum(II) metallacycles
Pollock, J. Bryant,Cook, Timothy R.,Stang, Peter J.
experimental part, p. 10607 - 10620 (2012/08/08)
A series of endohedral and exohedral amine-functionalized ligands were synthesized and used in the construction of supramolecular D2h rhomboids and a D6h hexagon. These supramolecular polygons were obtained via self-assembly of 120° dipyridyl donors with 180° or 120° diplatinum precursors when combined in 1:1 ratios. Steady-state absorption and emission spectra were collected for each ligand and metallacycle. Density functional theory (DFT) and time-dependent DFT calculations were employed to probe the nature of the observed optical transitions for the rhomboids. The emissive properties of these bis(phosphine) organoplatinum metallacycles arise from ligand-centered transitions involving π-type molecular orbitals with modest contributions from metal-based atomic orbitals. The D2h rhomboid self-assembled from 2,6-bis(4-pyridylethynyl)aniline and a 60° organoplatinum(II) acceptor has a low-energy excited state in the visible region and emits above 500 nm, properties which greatly differ from those of the parent 2,6-bis(4-pyridylethynyl)aniline ligand.
Post-assembly functionalization of organoplatinum(II) metallacycles via copper-free click chemistry
Chakrabarty, Rajesh,Stang, Peter J.
supporting information, p. 14738 - 14741 (2012/11/06)
We describe the use of a strain-promoted copper-free click reaction in the post-self-assembly functionalization of organoplatinum(II) metallacycles. The coordination-driven self-assembly of a 120° cyclooctyne-tethered dipyridyl donor with 60° and 120° di-Pt(II) acceptors forms molecular rhomboids and hexagons bearing cyclooctynes. These species undergo post-self-assembly [3+2] Huisgen cycloaddition with a variety of azides to give functionalized ensembles under mild conditions.
Synthesis and optical properties of 6-substituted-β-cyclodextrin derivatives
Guo, Ruiyun,Bagui, Mahuya,Wei, Yongge,Peng, Zhonghua
experimental part, p. 604 - 612 (2010/06/15)
β-Cyclodextrin derivatives with varying lengths of π-conjugated arms have been synthesized. Their structures have been confirmed by 1H NMR, elemental analysis, mass spectrometry and X-ray crystal structure determination. Their self-inclusion properties ar
Synthesis of new diethynylbenzene derivatives
Chimenti,Bolasco,Secci,Chimenti,Granese
, p. 2549 - 2555 (2007/10/03)
The preparation of new monomeric diacetylenic aromatic compounds is described.
