402956-36-9Relevant articles and documents
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
Charoenpattarapreeda, Jiraborrirak,Tan, Yaw Sing,Iegre, Jessica,Walsh, Stephen J.,Fowler, Elaine,Eapen, Rohan S.,Wu, Yuteng,Sore, Hannah F.,Verma, Chandra S.,Itzhaki, Laura,Spring, David R.
, p. 7914 - 7917 (2019)
Herein, we describe the development of a novel staple with an electrophilic warhead to enable the generation of stapled peptide covalent inhibitors of the p53-MDM2 protein-protein interaction (PPI). The peptide developed showed complete and selective covalent binding resulting in potent inhibition of p53-MDM2 PPI.
Photophysical and computational investigations of bis(phosphine) organoplatinum(II) metallacycles
Pollock, J. Bryant,Cook, Timothy R.,Stang, Peter J.
experimental part, p. 10607 - 10620 (2012/08/08)
A series of endohedral and exohedral amine-functionalized ligands were synthesized and used in the construction of supramolecular D2h rhomboids and a D6h hexagon. These supramolecular polygons were obtained via self-assembly of 120° dipyridyl donors with 180° or 120° diplatinum precursors when combined in 1:1 ratios. Steady-state absorption and emission spectra were collected for each ligand and metallacycle. Density functional theory (DFT) and time-dependent DFT calculations were employed to probe the nature of the observed optical transitions for the rhomboids. The emissive properties of these bis(phosphine) organoplatinum metallacycles arise from ligand-centered transitions involving π-type molecular orbitals with modest contributions from metal-based atomic orbitals. The D2h rhomboid self-assembled from 2,6-bis(4-pyridylethynyl)aniline and a 60° organoplatinum(II) acceptor has a low-energy excited state in the visible region and emits above 500 nm, properties which greatly differ from those of the parent 2,6-bis(4-pyridylethynyl)aniline ligand.
Synthesis and optical properties of 6-substituted-β-cyclodextrin derivatives
Guo, Ruiyun,Bagui, Mahuya,Wei, Yongge,Peng, Zhonghua
experimental part, p. 604 - 612 (2010/06/15)
β-Cyclodextrin derivatives with varying lengths of π-conjugated arms have been synthesized. Their structures have been confirmed by 1H NMR, elemental analysis, mass spectrometry and X-ray crystal structure determination. Their self-inclusion properties ar
