756499-81-7Relevant academic research and scientific papers
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
Charoenpattarapreeda, Jiraborrirak,Tan, Yaw Sing,Iegre, Jessica,Walsh, Stephen J.,Fowler, Elaine,Eapen, Rohan S.,Wu, Yuteng,Sore, Hannah F.,Verma, Chandra S.,Itzhaki, Laura,Spring, David R.
, p. 7914 - 7917 (2019/07/12)
Herein, we describe the development of a novel staple with an electrophilic warhead to enable the generation of stapled peptide covalent inhibitors of the p53-MDM2 protein-protein interaction (PPI). The peptide developed showed complete and selective covalent binding resulting in potent inhibition of p53-MDM2 PPI.
Donor-acceptor-substituted phenylacetylene macrocycles with threefold symmetry
Traber, Boris,Oeser, Thomas,Gleiter, Rolf
, p. 1283 - 1292 (2007/10/03)
A stepwise synthesis of the donor-acceptor-substituted macrocycle 5,21,37-tris(diethylamino)-13,29,45-trinitro[2.2.2.2.2.2]metacyclophane-1,9,17, 25,33,42-hexayne (1a) from 3,5-bis(3-iodo-5-nitrophenylethynyl)-N,N- diethylaniline (11) and 3,5-bis([3-dieth
Synthesis of new diethynylbenzene derivatives
Chimenti,Bolasco,Secci,Chimenti,Granese
, p. 2549 - 2555 (2007/10/03)
The preparation of new monomeric diacetylenic aromatic compounds is described.
Structures of N,N'-bis(1,2-dicarba-closo-dodecaboran-1-yl)-phenylureas: Building blocks for carborane-containing macromolecules
Songkram,Tanatani,Yamasaki,Yamaguchi,Kagechika,Endo
, p. 7065 - 7070 (2007/10/03)
We report the preparation and structural analysis of carborane-containing diphenylureas (1a-c and 2a-c). The secondary ureas (1) exist in trans-conformation. In spite of the bulkiness of the carborane cage, the N-methylated ureas (2) exist in cis-conforma
