402958-32-1

Basic information

• Product Name: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-
• Synonyms: 3-amino-N-cyclopropyl-2-hydroxyhexanamide
• CAS NO: 402958-32-1
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25142
• Mol File: 402958-32-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-(402958-32-1)
• EPA Substance Registry System: HexanaMide, 3-aMino-N-cyclopropyl-2-hydroxy-(402958-32-1)

Safety Data

• Hazardous Substances Data: 402958-32-1(Hazardous Substances Data)

Upstream product

• 765-30-0 Cyclopropylamine 
• 1053232-58-8 N-cyclopropyl-2-hydroxy-3-nitrohexanamide 
• 950483-70-2 C₉H₁₆N₄O₂ 

Downstream Products

• 1025023-97-5 C₃₅H₅₁N₉O₈ 
• 1025024-00-3 C₄₁H₅₅N₇O₈ 
• 1033880-44-2 C₄₀H₅₇N₉O₇ 
• 1033880-55-5 C₃₅H₅₄N₈O₇ 
• 1033880-61-3 C₄₃H₆₁N₉O₉ 
• 402958-99-0 (1S,3aR,6aS)-2-((S)-2-{(S)-2-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-acetylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid [1-(cyclopropylcarbamoyl-hydroxy-methyl)-butyl]-amide 
• 402958-60-5 3,4-dihydro-1H-isoquinoline-2-carboxylic acid 5-[1-(cyclopropylcarbamoyl-hydroxy-methyl)-butylcarbamoyl]-1-[3-methyl-2-(3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester 
• 757246-89-2 (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid [1-(cyclopropylcarbamoyl-hydroxy-methyl)-butyl]-amide 

Relevant articles and documents

A METHOD FOR THE PREPARATION OF 3-AMINO-N-CYCLOPROPYL-2-HYDROXYL-HEXANAMIDE

The present invention discloses a method for preparing 3-amino-N-cyclopropyl-2-hydroxyl-hexanamide. The invention relates to the technical field of the preparation of pharmaceutical intermediates. The method uses trans-2-hexenoic acid as the starting material, through the steps of epoxidation, ring-opening by nitrile, amidation, etc., to obtain the final product 3-amino-N-cyclopropyl-2-hydroxyl-hexanamide. The method uses easily-obtainable materials, requires mild reactive conditions, and adopts stable processes. Therefore it is suitable for large scale industrial production.

TERTIARY AMINE SUBSTITUTED PEPTIDES USEFUL AS INHIBITORS OF HCV REPLICATION

The present invention provides tertiary amine substituted peptides of Formula (I) useful as inhibitors of HCV replication. The variables R and R1-R12 in Formula I are described herein. The invention also includes methods for preparing such compounds. The present invention further includes pharmaceutical compositions containing tertiary amine substituted peptides and methods for using such compounds, including methods for using the compounds to treat hepatitis C infection.

Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.