402958-97-8

Basic information

• Product Name: Cyclopenta[c]pyrrole-1-carboxylic acid, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-, ethyl ester, (1S,3aR,6aS)-
• Synonyms: Cyclopenta[c]pyrrole-1-carboxylic acid, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-, ethyl ester, (1S,3aR,6aS)-;Cyclopenta[c]pyrrole-1-carboxylicacid,2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)aMino]acetyl]aMino]-3,3-diMethyl-1-oxobutyl]octahydro-,ethylester,(1S,3aR,6aS)-;(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyloctahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester;ethyl (3S,3aS,6aR)-2-[(2R)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylate
• CAS NO: 402958-97-8
• Molecular Formula: C₂₉H₄₃N₅O₅
• Molecular Weight: 542.69016
• Mol File: 402958-97-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopenta[c]pyrrole-1-carboxylic acid, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-, ethyl ester, (1S,3aR,6aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopenta[c]pyrrole-1-carboxylic acid, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-, ethyl ester, (1S,3aR,6aS)-(402958-97-8)
• EPA Substance Registry System: Cyclopenta[c]pyrrole-1-carboxylic acid, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-, ethyl ester, (1S,3aR,6aS)-(402958-97-8)

Safety Data

• Hazardous Substances Data: 402958-97-8(Hazardous Substances Data)

Usage

General Description

The chemical "Cyclopenta[c]pyrrole-1-carboxylic acid, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-, ethyl ester, (1S,3aR,6aS)-" is a complex compound that consists of cyclopenta[c]pyrrole-1-carboxylic acid, along with a combination of (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-Methyl-L-valyloctahydro-. Additionally, it contains an ethyl ester and has a stereochemistry of (1S,3aR,6aS)-. This chemical is likely to have specific uses in medical, pharmaceutical, or research contexts due to its complex structure and combination of functional groups.

Upstream product

• 1147103-42-1 (1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride 
• 402958-96-7 (S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid 
• 402958-25-2 (1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate 
• 402958-93-4 (S)-2-((S)-2-tert-Butoxycarbonylamino-2-cyclohexyl-acetylamino)-3,3-dimethyl-butyric acid methyl ester 
• 109183-71-3 N-(tert-butoxycarbonyl)-L-cyclohexylglycine 
• 98-97-5 2-pyrazylcarboxylic acid 

Downstream Products

• 402959-36-8 (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide 
• 402957-28-2 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide 
• 402958-99-0 (1S,3aR,6aS)-2-((S)-2-{(S)-2-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-acetylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid [1-(cyclopropylcarbamoyl-hydroxy-methyl)-butyl]-amide 
• 402958-98-9 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF TELAPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF

The invention relates to a process for the preparation of telaprevir, or a pharmaceutically acceptable salt or solvate thereof, wherein the process requires a smaller number of process steps and/or does not require the use of toxic and instable compounds compared to the known processes. Another embodiment refers to telaprevir, or a pharmaceutically acceptable salt or solvate thereof as well as to intermediate products for preparation of the same, wherein the afore-mentioned products are obtained by the process described herein.