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Telaprevir
Cas No: 402957-28-2
No Data No Data Metric Ton/Day Chemvon Biotechnology Co. Ltd. Contact Supplier
Wholesale high quality Telaprevir (VX-950) Cas 402957-28-2 with factory low price
Cas No: 402957-28-2
USD $ 100.0-100.0 / Kilogram 1 Kilogram 4000 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Telaprevir Manufacturer/High quality/Best price/In stock
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Telaprevir 402957-28-2 CAS NO.402957-28-2
Cas No: 402957-28-2
USD $ 1.0-3.0 / Kilogram 1 Kilogram 10 Kilogram/Day Hebei yanxi chemical co.,LTD. Contact Supplier
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Cas No: 402957-28-2
USD $ 145.0-157.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Telaprevir
Cas No: 402957-28-2
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Telaprevir
Cas No: 402957-28-2
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier

402957-28-2 Usage

Uses

Labeled Telaprevir, intended for use as an internal standard for the quantification of Telaprevir by GC- or LC-mass spectrometry.

Uses

Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease.

Uses

A labelled peptidomimetic inhibitor of hepatitis C virus protease.

Chemical Properties

White Solid

Definition

ChEBI: An oligopeptide consisting of N-(pyrazin-2-ylcarbonyl)cyclohexylalanyl, 3-methylvalyl, octahydrocyclopenta[c]pyrrole-1-carboxy, and 3-amino-N-cyclopropyl-2-oxohexanamide residues joined in sequence. Used f r treatment of chronic hepatitis C virus genotype 1 infection.
InChI:InChI=1/C36H53N7O6/c1-5-10-25(29(44)34(48)39-23-15-16-23)40-33(47)28-24-14-9-13-22(24)20-43(28)35(49)30(36(2,3)4)42-32(46)27(21-11-7-6-8-12-21)41-31(45)26-19-37-17-18-38-26/h17-19,21-25,27-28,30H,5-16,20H2,1-4H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t22-,24-,25?,27-,28-,30+/m0/s1

402957-28-2Synthetic route

(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide

(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
With Dess-Martin periodane In dichloromethane at 0 - 5℃; for 2h;93.61%
With sodium hypochlorite; sodium hydrogencarbonate; sodium bromide In dichloromethane; water at 0 - 5℃;90%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate In dichloromethane; water at 0 - 25℃; for 3 - 4h; Product distribution / selectivity;85%
C38H57N7O7
1257874-86-4

C38H57N7O7

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Stage #1: C38H57N7O7 With methanol; potassium carbonate at 20℃; for 0.5h;
Stage #2: With Dess-Martin periodane In dichloromethane at 20℃;
80%
Stage #1: C38H57N7O7 With potassium carbonate In methanol
Stage #2: With Dess-Martin periodane In dichloromethane
80%
(1S,3aR,6aS)-N-((S)-3-deutero-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxamide

(1S,3aR,6aS)-N-((S)-3-deutero-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxamide

A

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

B

[2H]-Telaprevir

[2H]-Telaprevir

Conditions
ConditionsYield
With Dess-Martin periodane In dichloromethane at 20℃; for 2h;A n/a
B n/a
[2H]-Telaprevir

[2H]-Telaprevir

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C
2.2: pH 3.5
3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h
4.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C
4.2: pH 3.5
5.1: dichloromethane / 72 h / 20 °C
6.1: potassium carbonate; methanol / 0.5 h / 20 °C
6.2: 20 °C
View Scheme
L-norvalinol
22724-81-8

L-norvalinol

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 20 - 80 °C
1.2: 1 h
1.3: DOWEX50wx8 / pH 7
2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
2.2: 48 h
3.1: bis(trichloromethyl) carbonate; 4-methyl-morpholine / dichloromethane / 3.08 h / -78 - -30 °C
4.1: dichloromethane / 72 h / 20 °C
5.1: potassium carbonate; methanol / 0.5 h / 20 °C
5.2: 20 °C
View Scheme
(S)-amino(cyclohexyl)acetic acid methyl ester
145618-11-7

(S)-amino(cyclohexyl)acetic acid methyl ester

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C
2.2: pH 3.5
3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h
4.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C
4.2: pH 3.5
5.1: dichloromethane / 72 h / 20 °C
6.1: potassium carbonate; methanol / 0.5 h / 20 °C
6.2: 20 °C
View Scheme
(2S)-cyclohexyl[(pyrazin-2-ylcarbonyl)amino]ethanoic acid
848777-30-0

(2S)-cyclohexyl[(pyrazin-2-ylcarbonyl)amino]ethanoic acid

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h
2.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C
2.2: pH 3.5
3.1: dichloromethane / 72 h / 20 °C
4.1: potassium carbonate; methanol / 0.5 h / 20 °C
4.2: 20 °C
View Scheme
(S)-methyl 2-cyclohexyl-2-(pyrazine-2-carboxamido)acetate
848777-29-7

(S)-methyl 2-cyclohexyl-2-(pyrazine-2-carboxamido)acetate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C
1.2: pH 3.5
2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h
3.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C
3.2: pH 3.5
4.1: dichloromethane / 72 h / 20 °C
5.1: potassium carbonate; methanol / 0.5 h / 20 °C
5.2: 20 °C
View Scheme
(S)-methyl 2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate
402958-95-6

(S)-methyl 2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C
1.2: pH 3.5
2.1: dichloromethane / 72 h / 20 °C
3.1: potassium carbonate; methanol / 0.5 h / 20 °C
3.2: 20 °C
View Scheme
(S)-N-(1-hydroxypentan-2-yl)formamide
1257874-84-2

(S)-N-(1-hydroxypentan-2-yl)formamide

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
1.2: 48 h
2.1: bis(trichloromethyl) carbonate; 4-methyl-morpholine / dichloromethane / 3.08 h / -78 - -30 °C
3.1: dichloromethane / 72 h / 20 °C
4.1: potassium carbonate; methanol / 0.5 h / 20 °C
4.2: 20 °C
View Scheme
(S)-1-(cyclopropylamino)-3-formamido-1-oxohexan-2-yl acetate
1257874-85-3

(S)-1-(cyclopropylamino)-3-formamido-1-oxohexan-2-yl acetate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: bis(trichloromethyl) carbonate; 4-methyl-morpholine / dichloromethane / 3.08 h / -78 - -30 °C
2.1: dichloromethane / 72 h / 20 °C
3.1: potassium carbonate; methanol / 0.5 h / 20 °C
3.2: 20 °C
View Scheme
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate
402958-25-2

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; diisopropyl-carbodiimide; copper dichloride / N,N-dimethyl-formamide / 5 h / 0 - 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1: copper dichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 22 h / 0 - 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: diisopropyl-carbodiimide; 4-methyl-morpholine; copper dichloride / N,N-dimethyl-formamide / 5 h / 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid
402958-96-7

(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; diisopropyl-carbodiimide; copper dichloride / N,N-dimethyl-formamide / 5 h / 0 - 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1: copper dichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 22 h / 0 - 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1: diisopropyl-carbodiimide; 4-methyl-morpholine; copper dichloride / N,N-dimethyl-formamide / 5 h / 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
(1S,3aR,6aS)-ethyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate
402958-97-8

(1S,3aR,6aS)-ethyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
3: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
3-(S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide
402960-19-4

3-(S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid
402958-98-9

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
2: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
(1S,3aR,6aS)-ethyl 2-(2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate

(1S,3aR,6aS)-ethyl 2-(2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; water / ethanol / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
3: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
(S)-ethyl 2,2-diethoxy-3-(((S)-1-phenylethyl)amino)hexanoate

(S)-ethyl 2,2-diethoxy-3-(((S)-1-phenylethyl)amino)hexanoate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 23 h / 20 - 25 °C
2: potassium hydroxide; water / ethanol / 23 h / 20 - 25 °C
3: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 24 h / 20 - 25 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 18 h / 20 - 25 °C
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
6: water; trifluoroacetic acid / acetone / 22 h
View Scheme
Multi-step reaction with 6 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 23 h / 20 °C / Inert atmosphere
2: potassium hydroxide / ethanol; water / 23 h / 20 °C
3: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-d6-formamide / 24 h / 20 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 20 °C
6: sulfuric acid / water; acetone / 17 h / 20 °C
View Scheme
(S)-ethyl 3-(((benzyloxy)carbonyl)amino)-2,2-diethoxyhexanoate

(S)-ethyl 3-(((benzyloxy)carbonyl)amino)-2,2-diethoxyhexanoate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: water; sodium hydroxide / ethanol / 24 h
2: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 40 h
3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
5: water; trifluoroacetic acid / acetone / 22 h
View Scheme
(S)-3-(((benzyloxy)carbonyl)amino)-2,2-diethoxyhexanoic acid

(S)-3-(((benzyloxy)carbonyl)amino)-2,2-diethoxyhexanoic acid

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 40 h
2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
4: water; trifluoroacetic acid / acetone / 22 h
View Scheme
(S)-benzyl (1-(cyclopropylamino)-2,2-diethoxy-1-oxohexan-3-yl)carbamate

(S)-benzyl (1-(cyclopropylamino)-2,2-diethoxy-1-oxohexan-3-yl)carbamate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
3: water; trifluoroacetic acid / acetone / 22 h
View Scheme
(S)-ethyl 3-amino-2,2-diethoxyhexanoate

(S)-ethyl 3-amino-2,2-diethoxyhexanoate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium carbonate / tetrahydrofuran / 20 h / 20 - 25 °C
2: water; sodium hydroxide / ethanol / 24 h
3: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 40 h
4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
6: water; trifluoroacetic acid / acetone / 22 h
View Scheme
(S)-3-amino-N-cyclopropyl-2,2-diethoxyhexanamide

(S)-3-amino-N-cyclopropyl-2,2-diethoxyhexanamide

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid
402958-98-9

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
2: water; trifluoroacetic acid / acetone / 22 h
View Scheme
ethyl (S)-3-(tert-butoxycarbonylamino)-2,2-diethoxyhexanoate

ethyl (S)-3-(tert-butoxycarbonylamino)-2,2-diethoxyhexanoate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium hydroxide; water / ethanol / 23 h / 20 - 25 °C
2: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 24 h / 20 - 25 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 18 h / 20 - 25 °C
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
5: water; trifluoroacetic acid / acetone / 22 h
View Scheme
Multi-step reaction with 5 steps
1: potassium hydroxide / ethanol; water / 23 h / 20 °C
2: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-d6-formamide / 24 h / 20 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 20 °C
5: sulfuric acid / water; acetone / 17 h / 20 °C
View Scheme
(S)-3-((tert-butoxycarbonyl)amino)-2,2-diethoxyhexanoic acid

(S)-3-((tert-butoxycarbonyl)amino)-2,2-diethoxyhexanoic acid

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 24 h / 20 - 25 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 18 h / 20 - 25 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
4: water; trifluoroacetic acid / acetone / 22 h
View Scheme
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-d6-formamide / 24 h / 20 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 20 °C
4: sulfuric acid / water; acetone / 17 h / 20 °C
View Scheme
(S)-tert-butyl (1-(cyclopropylamino)-2,2-diethoxy-1-oxohexan-3-yl)carbamate

(S)-tert-butyl (1-(cyclopropylamino)-2,2-diethoxy-1-oxohexan-3-yl)carbamate

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 18 h / 20 - 25 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide
3: water; trifluoroacetic acid / acetone / 22 h
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 20 °C
3: sulfuric acid / water; acetone / 17 h / 20 °C
View Scheme
(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1-oxo-2,2-diethoxyhexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1-oxo-2,2-diethoxyhexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
With water; trifluoroacetic acid In acetone for 22h; Reagent/catalyst;
With sulfuric acid In water; acetone at 20℃; for 17h;
(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide

(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide

A

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

B

C32H48N6O6

C32H48N6O6

C

C31H46N6O5

C31H46N6O5

Conditions
ConditionsYield
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium hydroxide In dichloromethane; water for 20.5h;A 20.3 g
B 0.8 g
C n/a
(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

C36H53N7O6

C36H53N7O6

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

VRT-127394

VRT-127394

Conditions
ConditionsYield
In acetonitrile at 37℃; for 72h; pH=9; Kinetics; pH-value; Reagent/catalyst; Solvent; Temperature; aq. buffer;

402957-28-2Upstream product

402957-28-2Downstream Products

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