40298-71-3

Basic information

• Product Name: BOC-TYR(2,6-DI-CL-BZL)-OH
• Synonyms: o-[(2,6-dichlorophenyl)methyl]-n-[(1,1-dimethylethoxy)carbonyl]-l-tyrosin;BOC-TYROSINE(2,6-DICHLORO-BZL)-OH;BOC-TYR(CL2-BZL);BOC-TYR(CL2-BZL)-OH;BOC-TYR(2,6-DI-CL-BZL)-OH;BOC-TYR(2,6-CL2-BZL)-OH;BOC-TYR(2,6-DICHLORO-BZL)-OH;BOC-O-(2,6-DICHLOROBENZYL)-L-TYROSINE
• CAS NO: 40298-71-3
• Molecular Formula: C₂₁H₂₃Cl₂NO₅
• Molecular Weight: 440.32
• EINECS: 254-876-6
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 40298-71-3.mol

Chemical Properties

• Melting Point: 128-130°C
• Boiling Point: 594°Cat760mmHg
• Flash Point: 313°C
• Appearance: /
• Density: 1.305g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• PKA: 2.98±0.10(Predicted)
• BRN: 3573263
• CAS DataBase Reference: BOC-TYR(2,6-DI-CL-BZL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-TYR(2,6-DI-CL-BZL)-OH(40298-71-3)
• EPA Substance Registry System: BOC-TYR(2,6-DI-CL-BZL)-OH(40298-71-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 40298-71-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BOC-TYR(2,6-DI-CL-BZL)-OH is used as an amino acid building block for peptide synthesis, which is essential for the development of new peptide-based drugs. The growing peptide drug market demands fast and reliable synthesis methods, and BOC-TYR(2,6-DI-CL-BZL)-OH contributes to achieving that goal.
Used in Biotechnology Industry:
BOC-TYR(2,6-DI-CL-BZL)-OH is also used as a key component in the development of biotechnological applications, such as the creation of novel bioactive peptides with specific functions. Its unique structure enables the design of peptides with enhanced properties, such as improved stability, selectivity, and bioavailability, which are crucial for various biotechnological applications.

InChI:InChI=1/C21H23Cl2NO5/c1-21(2,3)29-20(27)24-18(19(25)26)11-13-7-9-14(10-8-13)28-12-15-16(22)5-4-6-17(15)23/h4-10,18H,11-12H2,1-3H3,(H,24,27)(H,25,26)/t18-/m0/s1

Upstream product

• 85842-19-9 N-tert-Butoxycarbonyl-O-2,6-dichlorbenzyl-(S)-tyrosin Methylester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40298-69-9 4-(2,6-dichlorobenzyloxy)-L-phenylalanine 

Downstream Products

• 119089-47-3 Boc-Tyr(Cl₂-Bzl)-NHNH-Troc 
• 123196-92-9 Boc-Tyr(Cl₂-Bzl)-OBt 
• 146843-78-9 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionylamino}-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionic acid 2-oxo-2-phenyl-ethyl ester 
• 79985-48-1 Dynorphin A-(1-11) amide 
• 501082-71-9 Boc-Tyr(2,6-Cl₂Bzl)-Gly-Gly-Phe-OMe 
• 207613-94-3 Ac-Tyr-Ile-Gly-Ser-Arg-β-Ala-OH 
• 141801-26-5 endomorphin II 
• 189388-22-5 endomorphin 1 
• 443692-83-9 (S)-[2-(4-(2,6-dichloro-benzyloxy)-phenyl)-1-tert-butylcarbamoyl-ethyl]-carbamic acid tert-butyl ester 
• 1070383-27-5 1-[N-tert-butoxycarbonyl-O-(2,6-dichlorobenzyl)-L-tyrosyl]-piperidin-4-one 
• 1070383-25-3 [[[N-[(1,1-dimethylethoxy)carbonyl]-O-[(2,6-dichlorophenyl)methyl]-L-tyrosyl]amino]methylene]bis(phosphonic acid) tetraethyl ester 
• 1253041-18-7 Boc-Tyr(2,6-dichlorobenzyl)-O-t-Bu 

Relevant articles and documents

Synthesis and biological activity of N-substituted aminocarbonyl-1,3- dioxolanes as VLA-4 antagonists

A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.

A simple method for the alkaline hydrolysis of esters

A very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed.