403-12-3

Basic information

• Product Name: Ethanone, 2-fluoro-1-(3-nitrophenyl)- (9CI)
• Synonyms: Ethanone, 2-fluoro-1-(3-nitrophenyl)- (9CI)
• CAS NO: 403-12-3
• Molecular Formula: C₈H₆FNO₃
• Molecular Weight: 183.1365432
• Product Categories: ACETYLHALIDE
• Mol File: 403-12-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2-fluoro-1-(3-nitrophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-fluoro-1-(3-nitrophenyl)- (9CI)(403-12-3)
• EPA Substance Registry System: Ethanone, 2-fluoro-1-(3-nitrophenyl)- (9CI)(403-12-3)

Safety Data

• Hazardous Substances Data: 403-12-3(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-fluoro-1-(3-nitrophenyl)- (9CI) is a chemical compound with the molecular formula C8H6FNO3. It is a derivative of ethanone, also known as acetone, in which a fluoro group is substituted at the 2-position and a 3-nitrophenyl group is substituted at the 1-position. Ethanone, 2-fluoro-1-(3-nitrophenyl)- (9CI) is often used in research and pharmaceutical applications, as it possesses unique chemical properties that make it valuable for various processes. However, it is important to handle this compound with care, as its interactions with other chemicals and substances may have potentially harmful effects.

Upstream product

• 450-95-3 2-fluoroacetophenone 
• 2227-64-7 3'-nitro-2-bromoacetophenone 
• 121-89-1 3-Nitroacetophenone 
• 67-56-1 methanol 

Downstream Products

• 202197-29-3 1-benzyl-3-methyl-1H-indazol-5-ylamine 
• 1446417-99-7 2-fluoro-1-(3-nitrophenyl)ethanol 
• 1446417-92-0 2-fluoro-1-(3-nitrophenyl)ethanol 

Relevant articles and documents

Fluorination of α-bromomethyl aryl ketones with fluorohydrogenate-based ionic liquids

Fluorination of α-bromomethyl aryl ketones using fluorohydrogenate-based ionic liquids as fluorinating reagent is described. Reaction of various α-bromomethyl aryl ketones (1a-g) with fluorohydrogenate-based ionic liquids such as EMIMF·(HF)2.3, PYR13F·(HF)2.3 or PYR14F·(HF)2.3 as a fluoride ion source in anhydrous THF led to the formation of the corresponding α-fluoromethyl aryl ketones (2a-g) in very good yield. Compared to alternative fluorinating agents for this reaction, fluorohydrogenate-based ionic liquids are safer to handle and have the potential to be less expensive and more selective.

One-pot α-nucleophilic fluorination of acetophenones in a deep eutectic solvent

Two methods of nucleophilic fluorination to prepare α-fluoroacetophenones from α-bromoacetophenones by using KF with PEG-400 or TBAF with ZnF2 are described. On the fundamental of nucleophilic fluorination, a novel method of one-pot fluorination to prepare α-fluoroacetophenones directly from acetophenones in DES was developed.

Novel entry to aryl α-fluoromethyl ketones via sodium hydroxide-induced hydrolysis of fluorinated enol tosylates

Abstract: 1-Aryl-substituted 2,3,3-trifluoro-1-propenyl p-toluene-sulfonate 1 was smoothly hydrolyzed in a mixed solvent of dimethyl sulfoxide-water (1:1) in the presence of sodium hydroxide at 80 °C to afford the corresponding aryl α-monofluoromethyl ketones 2 in fair to good yields.