4031-84-9Relevant articles and documents
Development of 2-Morpholino-N-hydroxybenzamides as anti-proliferative PC-PLC inhibitors
Rees, Shaun W.P.,Leung, Euphemia,Reynisson, Jóhannes,Barker, David,Pilkington, Lisa I.
, (2021)
Phosphatidylcholine-specific phospholipase C (PC-PLC) is a key enzyme involved in the metabolism of the mammalian phospholipid phosphatidylcholine into secondary messengers diacylglycerol (DAG) and phosphocholine. DAG and phosphocholine have been identifi
Incorporation of a nitric oxide donating motif into novel pc-plc inhibitors provides enhanced anti-proliferative activity
Rees, Shaun W. P.,Rees, Tayla A.,Leung, Euphemia,Walker, Christopher S.,Barker, David,Pilkington, Lisa I.
, (2021/10/30)
Inhibition of phosphatidylcholine-specific phospholipase C (PC-PLC) has previously been shown to be a potential target for novel cancer therapeutics. One downstream consequence of PC-PLC activity is the activation of NF-κB, a nuclear transcription factor
Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors
Chenna, Bala Chandra,King, Jason R.,Shinkre, Bidhan A.,Glover, Amanda L.,Lucius, Aaron L.,Velu, Sadanandan E.
experimental part, p. 3752 - 3761 (2010/11/17)
Synthetic methods have been developed for lead Sortase A inhibitors identified from previous studies. Several derivatives of the lead inhibitor were synthesized to derive preliminary structure activity relationships (SAR). Different regions of the lead in
