40332-17-0

Basic information

• Product Name: (2-Methylbenzoimidazol-1-yl)acetic acid
• Synonyms: TIMTEC-BB SBB010829;ZERENEX E/5046020;(2-METHYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID;(2-METHYL-BENZOIMIDAZOL-1-YL)ACETIC ACID;(2-methyl-benzoimidazol-1-yl)-acetic acid 0.5 hydrate;1H-Benzimidazole-1-aceticacid,2-methyl-(9CI);2-METHYL-1H-BENZIMIDAZOLE-1-ACETIC ACID;2-(2-Methyl-1H-benzo[d]imidazol-1-yl)acetic acid
• CAS NO: 40332-17-0
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.2
• Product Categories: BENZIMIDAZOLE
• Mol File: 40332-17-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 260 °C
• Boiling Point: 431.7 °C at 760 mmHg
• Flash Point: 214.9 °C
• Appearance: /
• Density: 1.3 g/cm³
• Vapor Pressure: 3.21E-08mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: (2-Methylbenzoimidazol-1-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Methylbenzoimidazol-1-yl)acetic acid(40332-17-0)
• EPA Substance Registry System: (2-Methylbenzoimidazol-1-yl)acetic acid(40332-17-0)

Safety Data

• Hazard Codes: Xi,Xn,T
• Statements: 22-36/37/38-25
• Safety Statements: 22-26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 40332-17-0(Hazardous Substances Data)

Usage

General Description

(2-Methylbenzoimidazol-1-yl)acetic acid, also known as bimaziquil, is a chemical compound with potential medical applications. It belongs to a class of compounds called benzimidazoles, which have been studied for their potential as anti-inflammatory, anti-ulcer, and anti-cancer agents. This particular compound has been investigated for its ability to inhibit the enzyme carbonic anhydrase, which is involved in various physiological processes and has been targeted for the development of new drugs. Additionally, (2-Methylbenzoimidazol-1-yl)acetic acid has been studied for its potential to modulate the immune response and as a potential treatment for inflammatory and autoimmune diseases. Its unique structure and biological activities make it a promising candidate for further research and development in the medical and pharmaceutical fields.

InChI:InChI=1/C10H10N2O2/c1-7-11-8-4-2-3-5-9(8)12(7)6-10(13)14/h2-5H,6H2,1H3,(H,13,14)

Upstream product

• 615-15-6 2-Methyl-1H-benzimidazole 
• 7748-25-6 potassium chloroacetate 
• 79-11-8 chloroacetic acid 

Relevant articles and documents

COMPOSITIONS FOR TRANSFECTING A NUCLEIC ACID MOLECULE INTO A CELL COMPRISING HETEROCYCLIC COMPOUNDS GRAFTED TO A CATIONIC POLYMER, AND THEIR APPLICATIONS

The present invention relates to compositions for transfecting a nucleic acid molecule into a cell and their applications. The present invention is directed to a composition suitable for transfecting a nucleic acid molecule into a cell, preferably a eukaryotic cell, comprising (i) at least one compound of general formula (II) or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or an acceptable salt thereof, and (ii) an acceptable excipient, buffering agent, cell culture medium, or transfection medium, wherein Y11, Y22, Y33, Z11, Z22, Z33, Z44, Z55, Z66, Z77, X11, X22, R33, P++, R, T, U and V are as defined in the description. The present invention also relates to uses of said composition and to a method for in vitro or ex vivo transfection of live cells.

A benzimidazole compound and its preparation method and application

Provided are 2-substituted-N-[5-(2-(N-aryl methylene)amino-1,3,4-thiadiazole)-methylene]-benzimidazole and a preparation method and an application thereof. The preparation method comprises the steps: firstly, with a benzimidazole compound and potassium chloroacetate as raw materials and ethanol as a solvent, carrying out a reflux reaction to obtain a 1-carboxymethyl-benzimidazole compound; then with polyphosphoric acid, the 1-carboxymethyl-benzimidazole compound and thiosemicarbazide as raw materials, carrying out a reflux reaction to obtain 2-substituted-N-[5-(2-amino-1,3,4-thiadiazole)-methylene]-benzimidazole; then with 2-substituted-N-[5-(2-amino-1,3,4-thiadiazole)-methylene]-benzimidazole, aromatic aldehyde and p-toluenesulfonic acid as raw materials, carrying out a solid-phase reaction, and thus obtaining 2-substituted-N-[5-(2-(N-aryl methylene)amino-1,3,4-thiadiazole)-methylene]-benzimidazole. The preparation method has the advantages of simple reaction process, low equipment requirements, simple operation, relatively high target product yield, and small environmental pollution, and the prepared 2-substituted-N-[5-(2-(N-aryl methylene)amino-1,3,4-thiadiazole)-methylene]-benzimidazole can be applied in preparation of drugs inhibiting escherichia coli.