40332-58-9

Basic information

• Product Name: D-PENTAFLUOROPHE
• Synonyms: PENTAFLUORO-D-PHENYLALANINE;RARECHEM BK PT 0106;(R)-2-AMINO-3-PENTAFLUOROPHENYL-PROPIONIC ACID;H-PENTAFLUORO-D-PHE-OH;H-D-PHE(F 5)-OH;D-PENTAFLUOROPHE;D-PENTAFLUOROPHENYLALANINE;2,3,4,5,6-Pentafluoro-D-phenylalanine
• CAS NO: 40332-58-9
• Molecular Formula: C₉H₆F₅NO₂
• Molecular Weight: 255.14
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Amino Acid Derivatives;a-amino
• Mol File: 40332-58-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 286.3 °C at 760 mmHg
• Flash Point: 126.9 °C
• Appearance: /
• Density: 1.609 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.12±0.40(Predicted)
• CAS DataBase Reference: D-PENTAFLUOROPHE(CAS DataBase Reference)
• NIST Chemistry Reference: D-PENTAFLUOROPHE(40332-58-9)
• EPA Substance Registry System: D-PENTAFLUOROPHE(40332-58-9)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 40332-58-9(Hazardous Substances Data)

Usage

General Description

D-PENTAFLUOROPHE is a chemical compound that belongs to the class of pentafluorophenyl compounds, which are often used as building blocks in organic synthesis. This specific compound contains five fluorine atoms attached to a phenyl ring, giving it unique properties that make it valuable in various chemical reactions and applications. D-PENTAFLUOROPHE is commonly used as a reagent in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals due to its ability to selectively and efficiently introduce fluorine atoms into organic molecules. Its versatile nature and fluorine-rich structure make it an important and valuable chemical building block in the field of organic chemistry.

Upstream product

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Relevant articles and documents

Method for Preparing Unnatural Amino Acids

The present invention relates to a manufacturing method of unnatural amino acids and unnatural amino acids manufactured thereby. Specifically, the present invention relates to an asymmetric synthesis method which can manufacture unnatural amino acids having significantly high optical purity, and to the unnatural amino acids manufactured thereby. A manufacturing method of unnatural amino acids represented by chemical formula 6 or chemical formula 7 comprises the steps of: synthesizing a compound represented by chemical formula 4 or chemical formula 5; manufacturing a diol compound; and manufacturing a carboxylic acid compound.COPYRIGHT KIPO 2016

RESOLUTION AND USE IN α-AMINO ACID SYNTHESIS OF IMIDAZOLIDINONE GLYCINE DERIVATIVES

The imidazolidinones (rac.-1 and rac.-2) obtained from pivalaldehyde and glycine amides are resolved efficiently by crystallization of diastereomeric ammonium salts with chiral acids (mandelates and a gulonate respectively).The free bases are acylated under Schotten-Baumann conditions to give enantiomerically pure 1-Bz-, 1-BOC-, 1-Z- or 1-formyl-2-t-butyl-3-methyl- or -3-benzyl-4-imidazolidinones.Diastereoselective alkylation of the 3-methyl derivatives (BMI) with a variety of electrophiles (LDA/THF -70 to +25 degC) gives trans-disubstituted imidazolidinones exclusively (3-22).Some of these are hydrolyzed by a procedure employing excess acidic ion exchange resin to give enantiomerically pure (R)- or (S)-amino acids.The procedure is compared with other methods of generating chiral glycine enolates.