40348-71-8Relevant academic research and scientific papers
(2S,2′R)-Analogue of LG190178 is a major active isomer
Hakamata, Wataru,Sato, Yukiko,Okuda, Haruhiro,Honzawa, Shinobu,Saito, Nozomi,Kishimoto, Seishi,Yamashita, Atsushi,Sugiura, Takayuki,Kittaka, Atsushi,Kurihara, Masaaki
, p. 120 - 123 (2008/09/18)
Vitamin D receptor (VDR) ligands are therapeutic agents for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. VDR ligands also show immense potential as therapeutic agents for autoimmune diseases and cancers of the skin, prostat
Enantiomerically pure chiral pyridino-crown ethers: Synthesis and enantioselectivity toward the enantiomers of α-(1-naphthyl)ethylammonium perchlorate
Samu, Erika,Huszthy, Peter,Horvath, Gyoergy,Szoellosy, Aron,Neszmelyi, Andras
, p. 3615 - 3626 (2007/10/03)
Seven new enantiomerically pure chiral pyridino-crown ethers (S,S)-4- (R,R)-10 were prepared. Three of them [(S,S)-4, (S,S)-7 and (R,R)-10] contain one, and two of them [(S,S)-5 and (S,S)-8] contain two linker chains with a terminal double bond. These lin
Early transition metal alkoxide complexes bearing homochiral trialkanolamine ligands
Nugent, William A.,Harlow, Richard L.
, p. 6142 - 6148 (2007/10/02)
Enantiomerically pure trialkanolamines of the formula N(CH2CHROH)3, where R = methyl (3a), cyclohexyl (3b), teri-butyl (3c), or phenyl (3d), are readily synthesized by the reaction of ammonia with 3 equiv of an enantiopure epoxide. Trialkanolamines 3a-d replace n-propanol in tri-n-propyl vanadate to afford corresponding complexes 4a-d of the formula LV=O, where L is the deprotonated trialkanolamine. Similarly, (S,S,S)-triisopropanolamine 3a reacts with Ti(OiPr)4 to produce monomeric LTi(OiPr), 7a, which upon treatment with acetyl chloride gives the chloro complex LTiCl, 7b. The later group 5 ethoxides react with 3a to produce LM(OEt)2 (M = Nb, Ta). Partial hydrolysis of the Nb and Ta derivatives produces tetrameric μ-oxo-bridged structures which retain the trialkanolamine ligands. In all complexes the transition metal resides in a highly asymmetric environment, suggesting that this class of complexes may find use in the field of asymmetric catalysis. The X-ray crystal structures of complexes 4c and 7b are reported.
