403502-85-2

Usage

Chemical structure

A bicyclic compound with a phenyl group attached to the 7th position.

Chirality

A chiral compound with a stereochemistry of (6R,7S).

Applications

Commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals.

Biological activities

Exhibits various biological activities and is of interest for its potential therapeutic applications.

Research and development

Its unique structure and reactivity make it a valuable tool for synthetic chemistry research and development.

Upstream product

• 219915-67-0 4-methyl-N’-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfono hydrazide 
• 110-89-4 piperidine 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 

Relevant academic research and scientific papers

IMPROVEMENTS IN OR RELATING TO ORGANIC MATERIAL

The invention provides a method for the preparation of an intermediate for use in synthesizing a lower alkyl phenidate compound of formula (I), wherein each R1 independently represents an optionally substituted aryl, heteroaryl, alkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, sulfo or sulfhydryl group, R2 represents a hydrogen atom or a lower alkyl group, n represents an integer from 1 to 5 and m represents an integer from 1 to 3 or a pharmaceutically acceptable salt thereof; which method comprises the steps of: (a) flowing a tosylhydrazone compound of formula (IV), wherein R1, n and m are as defined above in relation to the methylphenidate of formula (I), an organic base and an organic solvent into a fluidic network; and (b) reacting the tosylhydrazone compound of formula (IV) and the base in the fluidic network under thermal and/or photochemical conditions to form a transient diazoamide compound of formula (V), wherein R1, n and m are as defined above in relation to the methylphenidate of formula (I).