219915-67-0

Usage

Uses

Given the lack of specific information on the uses of (E)-4-Methyl-N'-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide in the provided materials, it is not possible to list its applications with certainty. However, based on the presence of various functional groups and its complex structure, it can be inferred that (E)-4-Methyl-N'-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide may have potential applications in fields such as pharmaceuticals, materials science, or as an intermediate in the synthesis of other compounds. Further research and experimentation would be required to confirm its specific uses and benefits in these or other industries.

Upstream product

• 110-89-4 piperidine 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 14377-63-0 1-(phenylglyoxylyl)piperidine 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 403502-85-2 7-phenyl-1-aza-bicyclo[4.2.0]octan-8-one 
• 2629-91-6 7-phenyl-1-azabicyclo<4.2.0>octan-8-one 

Relevant academic research and scientific papers

IMPROVEMENTS IN OR RELATING TO ORGANIC MATERIAL

The invention provides a method for the preparation of an intermediate for use in synthesizing a lower alkyl phenidate compound of formula (I), wherein each R1 independently represents an optionally substituted aryl, heteroaryl, alkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, sulfo or sulfhydryl group, R2 represents a hydrogen atom or a lower alkyl group, n represents an integer from 1 to 5 and m represents an integer from 1 to 3 or a pharmaceutically acceptable salt thereof; which method comprises the steps of: (a) flowing a tosylhydrazone compound of formula (IV), wherein R1, n and m are as defined above in relation to the methylphenidate of formula (I), an organic base and an organic solvent into a fluidic network; and (b) reacting the tosylhydrazone compound of formula (IV) and the base in the fluidic network under thermal and/or photochemical conditions to form a transient diazoamide compound of formula (V), wherein R1, n and m are as defined above in relation to the methylphenidate of formula (I).

Impurity G generated in preparation process of methylphenidate hydrochloride, purifying method and application thereof

The invention provides an impurity G generated in a preparation process of methylphenidate hydrochloride, a purifying method and application thereof. The purifying method comprises the following steps of: 1) adding a crude product of the impurity G into a

Process for the preparation of dexmethylphenidate hydrochloride

The present invention provides a new and efficient process for the preparation of the dexmethylphenidate hydrochloride with high optical purity, the process comprising: (a) reacting a solution of threo-N-Boc-ritalinic acid with (S)-1-phenylethylamine, separating precipitated solid salt of (R,R)-enriched N-Boc-ritalinic acid with (S)-1-phenylethylamnine from the reaction mixture and recrystallizing, reslurring and/or trituring of said salt; (b) mixing the solid salt of (R,R)-N-Boc-ritalinic acid and (S)-1-phenylethylamine obtained in step (a) with aqueous acid and separating (R,R)-N-Boc-ritalinic acid from the mixture; and (c) reacting the (R,R)-N-Boc-ritalinic acid prepared in step (b) with hydrogen chloride and methanol to give dexmethylphenidate hydrochloride with optical purity of at least 99% ee. The present invention further provides salt of (R,R)-N-Boc-ritalinic acid with (S)-1-phenylethylamine as new intermediate in the preparation of dexmethylphenidate hydrochloride.