40358-29-0

Usage

Type of compound

Heterocyclic compound

Structure

Contains a benzene ring fused to a thiazepine ring

Derivation

Derived from the thiazepine class of compounds

Usage

Potential therapeutic agent in the pharmaceutical industry

Medical applications

Treatment of various medical disorders, including anxiety and depression

Importance

Promising candidate for drug development and further research in medicinal chemistry

Upstream product

• 141-79-7 4-methyl-pent-3-en-2-one 
• 137-07-5 2-amino-benzenethiol 
• 66647-68-5 4-bromo-4-methylpentan-2-one 
• 136-95-8 2-amino-benzthiazole 
• 1141-88-4 2-Aminophenyl disulfide 
• 108-10-1 4-methyl-2-pentanone 

Downstream Products

• 25111-89-1 2,2-dimethyl-2,3-dihydro-benzothiazole 
• 120362-84-7 2,3-Dihydro-2,2-dimethyl-4-(2-methyl-1-propenyl)-1,5-benzothiazepin 
• 120362-85-8 6,6,9,9,11-Pentamethyl-7,9-dihydro-6H-5-thia-11a-aza-dibenzo[a,c]cycloheptene 
• 120362-81-4 7,9-Dihydro-11-(2-methyl-1-propenyl)-6,6,9,9-tetramethyl-6H-pyrido<2,1-d><1,5>benzothiazepin 
• 101890-91-9 2,3-Dihydro-2,2-dimethyl-4-(2-phenylethenyl)-1,5-benzothiazepin 
• 102013-13-8 2,2-dimethyl-4-(4-methyl-trans-styryl)-2,3-dihydro-benzo[b][1,4]thiazepine 

Relevant academic research and scientific papers

Synthesis, characterization, crystal structures, and anticancer activity of some new 2,3-dihydro-1,5-benzoxazepines

Various benzoxazepine derivatives have been synthesized and characterized using IR, NMR, GC–MS, and microanalysis. The single-crystal X-ray structures of 2,2-dimethyl-4-[(E)-2-(4-methylphenyl)ethenyl]-2,3-dihydro-1,5-benzoxazepine (RS01), 4-[(E)-2-(2-chlo

A simple and efficient method for synthesis of benzothiazepine derivatives

A series of 1, 5-benzothiazepines were synthesized using disulfides and α, β-unsaturated carbonyl or nitrile compounds as reaction substrates. After reductive cleavage of the S-S bond of disulfides, the resulting thiols were reacted with α,β-unsaturated carbonyl or nitrile compounds to generated seven-membered heterocyclic compounds. In the presence of ammonium thioglycolate, the Michael reaction occurred between disulfides (1) and 4-methyl-3-penten-2-one to give 2, 2, 4-trymethyl-3H-1, 5-benzothiazepine derivatives in good yields. When ethyl acrylate or acrylonitrile was used as the Michael acceptor, 90-99% of (2-amino- phenylsulfanyl)propionitriles (3) and/or 92-99% of (2-amino-phenylsulfanyl) propionic acid ethyl esters (4) were produced. Subsequently, the 1, 5-benzothiazepine compounds 5 and 6 were obtained due to the cyclization reaction. The Japan Institute of Heterocyclic Chemistry.

Process for the ring chlorination of aromatic hydrocarbons

Aromatic hydrocarbons which are monosubstituted by straight-chain or branched C1 -C12 -alkyl or by C3 -C8 -cycloalkyl can be chlorinated in the presence of Friedel-Crafts Catalysts in liquid phase on the aromatic ring if cyclic benzo-fused imines or benzo[f]-1,4-thiazepines are used as co-catalysts. This makes it possible to obtain a higher proportion of p-isomers.