403597-66-0

Usage

General Description

1H-Indole, 3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)- is a chemical compound with the molecular formula C17H15NO5S. It contains an indole ring and a phenylsulfonyl group, as well as a 1,3-dioxolane substituent. 1H-Indole, 3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)- has potential applications in pharmaceutical research and drug development, as indole derivatives have been found to exhibit a wide range of biological activities. The presence of the phenylsulfonyl group in its structure suggests that the compound may possess sulfone-related properties. Further research and testing may elucidate the specific characteristics and potential uses of this chemical.

Upstream product

• 80360-20-9 1-(phenylsulfonyl)indole-3-carbaldehyde 
• 107-21-1 ethylene glycol 
• 487-89-8 Indole-3-carboxaldehyde 
• 98-09-9 benzenesulfonyl chloride 
• 120-72-9 indole 

Downstream Products

• 1026746-03-1 1-(1-benzenesulfonyl-3-[1,3]dioxolan-2-yl-1H-indol-2-yl)-octan-1-ol 
• 1026694-66-5 (1-benzenesulfonyl-3-[1,3]dioxolan-2-yl-1H-indol-2-yl)-phenyl-methanol 
• 89241-37-2 4-(phenylsulfonyl)-4H-furo<3,4-b>indole 
• 143774-50-9 3-methyl-4-(phenylsulfonyl)-4H-furo<3,4-b>indole 
• 143774-52-1 3-phenyl-4-(phenylsulfonyl)-4H-furo<3,4-b>indole 
• 403597-68-2 3-heptyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole 

Relevant academic research and scientific papers

Synthesis of an azide-tethered 4H-furo[3,4-b]indole

We describe the synthesis of a novel azide-tethered 4H-furo[3,4-b]indole as a putative intermediate for a projected route to the 2-acylindole class of indole alkaloids. O N3 Me N N N H N H H O

An efficient synthesis of 4-(phenylsulfonyl)-4H-furo[3,4-b]indoles

The fused heterocycle 4-(phenylsulfonyl)-4H-furo-[3,4-b]indole, which is an indole-2,3-quinodimethane synthetic analogue, is prepared in five steps from indole in 46% yield. A similar sequence is used to synthesize C-3 derivatives (3-methyl, 3-phenyl, and 3-heptyl). Thus, indole-3-carbaldehyde (1) is protected as the N-phenylsulfonyl derivative 2 and converted to the ethylene acetal 6. Lithiation at C-2 followed by treatment with an aldehyde affords the expected hydroxy acetals 7 and 8. Exposure to acid effects cyclization to the furoindoles 5 and 9. Furthermore, C-1 lithiation of furo[3,4-b]indole 9c followed by treatment with methyl iodide affords disubstituted furo[3,4-b]indole 10.