403646-47-9

Basic information

• Product Name: 5-Bromo-2-(trifluoromethoxy)benzoic acid
• Synonyms: Benzoic acid, 5-bromo-2-(trifluoromethoxy)-;5-Bromo-2-(trifluoromethoxy)benzoic acid
• CAS NO: 403646-47-9
• Molecular Formula: C₈H₄BrF₃O₃
• Molecular Weight: 285.01
• Mol File: 403646-47-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287 °C
• Flash Point: 127 °C
• Appearance: /
• Density: 1.797
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.518
• PKA: 2.53±0.36(Predicted)
• CAS DataBase Reference: 5-Bromo-2-(trifluoromethoxy)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-(trifluoromethoxy)benzoic acid(403646-47-9)
• EPA Substance Registry System: 5-Bromo-2-(trifluoromethoxy)benzoic acid(403646-47-9)

Safety Data

• Hazardous Substances Data: 403646-47-9(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-(trifluoromethoxy)benzoic acid is a chemical compound with the molecular formula C8H4BrF3O3. It is a derivative of benzoic acid, with a bromine atom and a trifluoromethoxy group attached to the benzene ring. 5-Bromo-2-(trifluoromethoxy)benzoic acid is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the fields of medicine and agriculture due to its unique molecular structure. Additionally, its halogen and trifluoromethoxy substituents give it interesting properties for use in organic synthesis and as a research tool in the laboratory.

InChI:InChI=1/C8H4BrF3O3/c9-4-1-2-6(15-8(10,11)12)5(3-4)7(13)14/h1-3H,(H,13,14)

Upstream product

• 773135-66-3 ethyl 5-bromo-2-(trifluoromethoxy)benzoate 
• 124-38-9 carbon dioxide 
• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 

Downstream Products

• 685126-86-7 (5-bromo-2-(trifluoromethoxy)phenyl)methanol 
• 773874-13-8 methyl 5-bromo-2-(trifluoromethoxy)benzoate 
• 1108613-16-6 N-[2-Cyano-1-(1H-indol-3-ylmethyl)-ethyl]-5-bromo-2-trifluoromethoxy-benzamide 
• 1262620-41-6 C₁₀H₈BrF₃N₂O₃ 
• 1454928-23-4 methyl 2-(5-bromo-2-(trifluoromethoxy)phenyl)acetate 
• 1454928-22-3 1-(5-bromo-2-(trifluoromethoxy)phenyl)-2-diazoethanone 
• 1616930-68-7 5-Bromo-N-methoxy-N-methyl-2-(trifluoromethoxy)benzamide 
• 1616930-97-2 1-(5-Bromo-2-(trifluoromethoxy)phenyl)ethan-1-one 
• 1262620-37-0 2-(5-bromo-2-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol 

Relevant articles and documents

FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS

The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Cyanomethyl substituted N-Acyl Tryptamines

The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula I in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and

1,2-Didehydro-3- and -4-(trifluoromethoxy)benzene: The "aryne" route to 1- and 2-(trifluoromethoxy)naphthalenes

Upon treatment of 1-bromo-2-(trifluoromethoxy)benzene with lithium diisopropylamide (LIDA) at -100°C, 3-bromo-2-(trifluoromethoxy)phenyllithium is generated. It can be trapped as such, but isomerizes to afford 2-bromo-6-(trifluoromethoxy)phenyllithium whe