403664-85-7Relevant academic research and scientific papers
Synthesis of the Aziridinomitosene Skeleton by Intramolecular Michael Addition of α-Lithioaziridines: An Aromatic Route Featuring Deuterium as a Removable Blocking Group
Vedejs, Edwin,Little, Jeremy D.
, p. 1794 - 1799 (2007/10/03)
A convergent synthetic route to the 1,2-aziridinopyrrolo(1,2-a)indole 34 has been developed. Key features of this route include the deuterium kinetic isotope effect to block undesired indole lithiation during tin-lithium exchange from 27a to 30a, the intr
Aziridinomitosenes by anionic cyclization: Deuterium as a removable blocking group
Vedejs, Edwin,Little, Jeremy
, p. 748 - 749 (2007/10/03)
Treatment of 11a with methyllithium affords the destannylated product 12 together with a small amount of tetracyclic product derived from intramolecular Michael addition. The same procedure from the deuterated analogue 11b gives the tetracyclic 18 as the
