403664-87-9Relevant academic research and scientific papers
Aziridinomitosenes by anionic cyclization: Deuterium as a removable blocking group
Vedejs, Edwin,Little, Jeremy
, p. 748 - 749 (2002)
Treatment of 11a with methyllithium affords the destannylated product 12 together with a small amount of tetracyclic product derived from intramolecular Michael addition. The same procedure from the deuterated analogue 11b gives the tetracyclic 18 as the
Synthesis of the Aziridinomitosene Skeleton by Intramolecular Michael Addition of α-Lithioaziridines: An Aromatic Route Featuring Deuterium as a Removable Blocking Group
Vedejs, Edwin,Little, Jeremy D.
, p. 1794 - 1799 (2007/10/03)
A convergent synthetic route to the 1,2-aziridinopyrrolo(1,2-a)indole 34 has been developed. Key features of this route include the deuterium kinetic isotope effect to block undesired indole lithiation during tin-lithium exchange from 27a to 30a, the intr
