403695-15-8Relevant academic research and scientific papers
Design, synthesis and preliminary evaluation of novel 3′-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors
Pellicciari, Roberto,Costantino, Gabriele,Marinozzi, Maura,Macchiarulo, Antonio,Amori, Laura,Josef Flor, Peter,Gasparini, Fabrizio,Kuhn, Rainer,Urwyler, Stephan
, p. 3179 - 3182 (2007/10/03)
Two novel 3′-substituted carboxycylopropylglycines, (2S,1′S,2′S,3′R)-2-(3′-xanthenylmethyl-2′- carboxycyclopropyl)glycine (8a) and (2S,1′S,2′S,3′R)-2-(3′-xanthenylethyl-2′- carboxycyclopropyl)glycine (8b), were synthesized and evaluated as mGluR ligands. Compound 8b showed to be a potent group II antagonist with submicromolar activity.
