403697-33-6

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 849519-04-6 2-(3,4-dimethoxy-phenyl)-4-[1,3]dioxolan-2-yl-butyronitrile 
• 849519-05-7 (tert-butyl-dimethyl-silanyl)-[2-(3,4-dimethoxy-phenyl)-4-[1,3]dioxolan-2-yl-but-1-enylidene]-amine 
• 108-24-7 acetic anhydride 

Downstream Products

• 36622-29-4 (S)-verapamil 
• 849519-06-8 (S)-2-(3,4-Dimethoxy-phenyl)-2-(2-[1,3]dioxolan-2-yl-ethyl)-3-methyl-but-3-enenitrile 
• 849519-07-9 (S)-2-(3,4-Dimethoxy-phenyl)-2-(2-[1,3]dioxolan-2-yl-ethyl)-3-methyl-butyronitrile 

Relevant academic research and scientific papers

Nucleophile-catalyzed asymmetric acylations of silyl ketene imines: Application to the enantioselective synthesis of verapamil

All-carbon quaternary stereocenters are generated with good enantioselectivity through a nucleophile-catalyzed acylation reaction of silyl ketene imines (see scheme, TBS = tert-butyldimethylsilyl). The method is applied to the first catalytic asymmetric synthesis of the drug verapamil.