403731-51-1Relevant articles and documents
Total synthesis of nucleobase-modified adenophostin A mimics
Shuto, Satoshi,Horne, Graeme,Marwood, Rachel D.,Potter, Barry V. L.
, p. 4937 - 4946 (2007/10/03)
The adenophostins exhibit approximately 10-100 times higher receptor binding and Ca2+ mobilising potencies in comparison with the natural second messenger D-myo-inositol 1,4,5-trisphosphate [InS(1,4,5)P3]. Despite many synthetic atte
Convergent synthesis of adenophostin A analogues via a base replacement strategy
Marwood, Rachel D.,Shuto, Satoshi,Jenkins, David J.,Potter, Barry V. L.
, p. 219 - 220 (2007/10/03)
The first totally synthetic base-modified analogues of the natural product and potent D-myo-inositol 1,4,5-trisphosphate receptor agonist adenophostin A were efficiently synthesised from D-xylose and D-glucose using methodology employing base and surrogate base addition to a common disaccharide intermediate.