403793-48-6

Basic information

• Product Name: 1-(3-ISOPROPYL-2-METHYL-3H-IMIDAZOL-4-YL)-ETHANONE
• Synonyms: 1-(3-ISOPROPYL-2-METHYL-3H-IMIDAZOL-4-YL)-ETHANONE;Ethanone, 1-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]- (9CI);1-(1-isopropyl-2-Methyl-1H-iMidazol-5-yl)ethanone;1-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]ethanone;5-Acetyl-1-isopropyl-2-methylimidazole
• CAS NO: 403793-48-6
• Molecular Formula: C9H14N2O
• Molecular Weight: 166.22026
• Product Categories: ISOPROPYL;ACETYLGROUP;AMINETERTIARY;CMLLYL
• Mol File: 403793-48-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 294.5±13.0 °C(Predicted)
• Appearance: /
• Density: 1.05±0.1 g/cm3(Predicted)
• PKA: 4.89±0.44(Predicted)
• CAS DataBase Reference: 1-(3-ISOPROPYL-2-METHYL-3H-IMIDAZOL-4-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-ISOPROPYL-2-METHYL-3H-IMIDAZOL-4-YL)-ETHANONE(403793-48-6)
• EPA Substance Registry System: 1-(3-ISOPROPYL-2-METHYL-3H-IMIDAZOL-4-YL)-ETHANONE(403793-48-6)

Safety Data

• Hazardous Substances Data: 403793-48-6(Hazardous Substances Data)

Usage

General Description

The chemical 1-(3-isopropyl-2-methyl-3H-imidazol-4-yl)-ethanone is a compound with the molecular formula C10H14N2O. It is an organic compound containing a ketone functional group and an imidazole ring. This chemical is used in pharmaceutical research and may have potential therapeutic applications. Its structure and properties make it a valuable component in drug discovery and development, as it may have biological activity related to its imidazole moiety. Further research is necessary to fully understand its potential applications and effects.

Upstream product

• 75-30-9 2-iodo-propane 
• 78210-66-9 1-(2-methyl-1H-imidazol-4-yl)ethanone 
• 42717-36-2 N-isopropylethanimidamide 
• 82982-51-2 3-bromo-4-methoxy-3-buten-2-one 
• 5844-71-3 3-bromo-4,4-dimethoxybutan-2-one 
• 909712-04-5 N-isopropyl-acetamidine hydrochloride 
• 77070-88-3 3-chloro-4,4-diethoxy-butan-2-one 
• 403793-47-5 5-methyl-4-(N-isopropylacetamido)isoxazole 

Relevant articles and documents

Concise, flexible syntheses of 4-(4-imidazolyl)pyrimidine cyclin-dependent kinase 2 (CDK2) inhibitors

A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4,4-dimethoxy-2-butanone and amidines, which provides acetyl-imidazoles and late stage palladium-catalyzed N-arylation to give the target pyrimidine derivatives.

Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors

An imidazole series of cyclin-dependent kinase (CDK) inhibitors has been developed. Protein inhibitor structure determination has provided an understanding of the emerging structure activity trends for the imidazole series. The introduction of a methyl sulfone at the aniline terminus led to a more orally bioavailable CDK inhibitor that was progressed into clinical development.

Imidazolo-5-YL-2anilino-pyrimidines as agents for the inhibition of the cell proliffration

Compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.