77070-88-3Relevant academic research and scientific papers
TETRAAZA-CYCLOPENTA[A]INDENYL DERIVATIVES
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Page/Page column 91, (2015/01/09)
The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic M1 mediator.
Tetraaza-cyclopenta[a]indenyl derivatives
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Paragraph 0075, (2015/01/18)
The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic M1 mediator.
TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS
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Page/Page column 83, (2013/07/05)
The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic M1 mediator.
(IMIDAZOLO-5-YL)-2-ANILO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION
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Page/Page column 74, (2008/06/13)
Compounds of the formula (I): wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti cell proliferation) effect in a warm blooded animal, such as man.
Synthesis of 2-Substituted 5-Acetyl-1(H)-imidazoles via 3-Chloro-4,4-dimethoxy-2-butanone and Related 3,4-Disubstituted 3-Buten-2-ones
Reiter, Lawrence A.
, p. 3494 - 3498 (2007/10/02)
A variety of 3,4-disubstituted 3-buten-2-ones have been synthesized and reacted with acetamidine to yield 5-acetyl-2-methyl-1(H)-imidazoles, 5-substituted pyrimidines, or both.The nature of the product depends on the substituents at position 3 and 4 of th
Process for preparation of 4-acetyl-2-substituted-imidazoles
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, (2008/06/13)
Novel intermediates of the formula STR1 where R1 and R2 are each (C1 -C4)alkyl or taken together are (C2 -C4)alkylene, and their use in a process for preparation of compounds of the formula STR2 where R is (C1 -C6)alkyl or (CH2)n Ar, Ar is phenyl or phenyl monosubstituted by Cl, Br, F, CH3 or OCH3 and n is 2 to 4; which comprises contacting one of said intermediates with an amidine of formula STR3 in the presence of reaction inert solvent and base; and a process for preparing a further intermediate, 1,2-dichloro-1-buten-3-one.
A Procedure for Diethoxymethylation of Ketones
Mock, William L.,Tsou, Hwei-Ru
, p. 2557 - 2561 (2007/10/02)
Reaction of a number of ketones with diethoxycarbenium fluoroborate in the presence of N,N-diisopropylethylamine at low temperature in methylene chloride results in a preparatively useful conversion to α-(diethoxymethyl) ketones.The method is compatible with arene, nitrile, chloride, and ester functional groups.With unsymmetrically substituted ketones, it is regioselective for the less substituted α-position.In favorable cases α,α'-dialkylation occurs.Conjugated ketones react normally at the saturated position adjacent to the carbonyl group.The mechanism of the reaction is considered.
