40395-08-2Relevant academic research and scientific papers
Phamaceutical composition for preventing or treating cancer comprising 2,6-Dibenzyl-4-chlorophenol compound
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Paragraph 0020; 0024-0028, (2017/05/25)
The present invention relates to a pharmaceutical composition for preventing or treating a cancer comprising 2,6-dibenzyl-4-chlorophenol compound. The 2,6-dibenzyl-4-chlorophenol compound suppresses proliferation of the cancer cells in a concentration-dependent manner at A549 cells, DU145 cells, Hela cells and HepG2 cells. The 2,6-dibenzyl-4-chlorophenol compound of the present invention can be utilized as the composition for preventing or treating the cancer.COPYRIGHT KIPO 2017
Identification, library synthesis and anti-vibriosis activity of 2-benzyl-4-chlorophenol from cultures of the marine bacterium Shewanella halifaxensis
Moore, Sarah L.,Berthomier, Lucile,Braganza, Chriselle D.,MacKichan, Joanna K.,Ryan, Jason L.,Visnovsky, Gabriel,Keyzers, Robert A.
supporting information, p. 3086 - 3088 (2016/06/13)
Summer Gut Syndrome (SGS) is caused by various Vibrio bacterial species and can have negative effects on aquaculture farms worldwide. In New Zealand, SGS is caused by Vibrio harveyii infecting King Salmon (Oncorhynchus tshawytscha). To find leads for the prevention of SGS, we screened the inhibitory effects of 16 strains of Shewanella upon V. harveyii growth in competitive solid phase cultures. The detailed investigation of Shewanella halifaxensis IRL548 revealed 2-benzyl-4-chlorophenol (1), a known, commercially available antibacterial agent, as the major bioactive component. Synthesis of a small library of congeners to confirm the natural product identity and to provide a structure-activity relationship for the observed activity was also completed. Compound 1 exhibits moderate activity against two pathogenic microorganisms.
