40412-61-1

Upstream product

• 40412-60-0 (S)-3-Cyclohexyl-3-methyl-indan-1-one 
• 4420-58-0 2-cyclohexyl-2-phenylpropanenitrile 
• 108-85-0 1-bromocyclohexane 
• 1310343-28-2 3-(2-bromophenyl)-N-methoxy-N-methylpropanamide 
• 1092491-47-8 C₁₅H₁₉BrO 
• 33817-23-1 (S)-2-cyclohexyl-2-phenylpropanoic acid 
• 40412-59-7 (S)-3-Cyclohexyl-3-phenyl-butyric acid 

Relevant academic research and scientific papers

Nickel-Catalyzed Asymmetric Reductive Arylalkylation of Unactivated Alkenes

Reported is an asymmetric reductive dicarbofunctionalization of unactivated alkenes. Under the catalysis of a Ni/BOX system, various aryl bromides, incorporating a pendant olefinic unit, were successfully reacted with an array of primary alkyl bromides in the presence of Zn as a reductant, furnishing a series of benzene-fused cyclic compounds bearing a quaternary stereocenter in high enantioselectivities. Notably, this reaction avoids the use of pregenerated organometallics and demonstrates high tolerance of sensitive functionalities. The preliminary mechanistic investigations reveal that this Ni-catalyzed reaction proceeds as a cascade consisting of migratory insertion and cross-coupling with a nickel(I)-mediated intramolecular 5-exo cyclization as the enantiodetermining step.

Nickel-catalyzed asymmetric intramolecular reductive heck reaction of unactivated alkenes

An asymmetric Ni-catalyzed intramolecular reductive Heck reaction of unactivated alkenes tethered to aryl bromides has been accomplished, providing a variety of benzene-fused cyclic compounds bearing a quaternary stereogenic center in good to excellent yi