4043-59-8

Basic information

• Product Name: 1,3-Diethoxy-2-propanol
• Synonyms: 1,3-DIETHOXY-2-PROPANOL 96+%;Glycerol α,α'-diethyl ether;Glycerol α,γ-diethyl ether;1,3-Diethoxy-2-propa;1,3-diethoxy-2-propano;1,3-glycerindiethylether;diethylin;glycerol1,3-bis(ethylether)
• CAS NO: 4043-59-8
• Molecular Formula: C₇H₁₆O₃
• Molecular Weight: 148.2
• EINECS: 223-736-6
• Mol File: 4043-59-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 191-192°C
• Flash Point: 191-192°C
• Appearance: /
• Density: 0,95 g/cm3
• Vapor Pressure: 0.0447mmHg at 25°C
• Refractive Index: 1.4120
• Storage Temp.: Store below +30°C.
• PKA: 13.71±0.20(Predicted)
• CAS DataBase Reference: 1,3-Diethoxy-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diethoxy-2-propanol(4043-59-8)
• EPA Substance Registry System: 1,3-Diethoxy-2-propanol(4043-59-8)

Safety Data

• Safety Statements: 24/25
• RIDADR: 1993
• WGK Germany: WGK 3 highly water endangering
• RTECS: UB1476750
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 4043-59-8(Hazardous Substances Data)

Usage

Uses

1,3-Diethoxy-2-propanol is used to prepare 3-(4-benzyloxyphenyl)propanoic acid derivatives, useful as GPR40 receptor modulators.

InChI:InChI=1/C7H16O3/c1-3-9-5-7(8)6-10-4-2/h7-8H,3-6H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 96-23-1 1,3-Dichloro-2-propanol 
• 856976-66-4 glycerol-1.3-divinyl ether 
• 5460-70-8 1,3-diethoxypropan-2-one 
• 74-96-4 ethyl bromide 
• 56-81-5 glycerol 
• 106-89-8 epichlorohydrin 
• 3188-13-4 ethyl chloromethyl ether 
• 109-94-4 formic acid ethyl ester 
• 141-52-6 sodium ethanolate 

Downstream Products

• 5460-70-8 1,3-diethoxypropan-2-one 
• 4862-86-6 5-Jod-isophthalsaeure-bis-<1,3-diaethoxy-propyl-(2)-ester> 
• 222634-40-4 ethyl 2-(1-(1,3-diethoxy-2-propoxycarbonyloxy)-2-methylpropyl)-5-(5-isopropoxy-4-methoxy-2-nitrobenzoyl)-2H-1,2,3-triazole-4-carboxylate 
• 335653-51-5 7-benzylthio-3-(2-chlorophenyl)-1-(2-ethoxy-1-ethoxymethylethyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 
• 1028718-19-5 3-{4-[2-ethoxy-1-(ethoxymethyl)ethoxy]phenyl}-2-ethyl-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one 
• 7748-36-9 oxetan-3-ol 
• 926297-35-0 ethyl (2E)-3-{2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-[2-ethoxy-1-(ethoxymethyl)ethoxy]phenyl}acrylate 
• 91-22-5 quinoline 
• 28239-63-6 Thiophosphoric acid O-(2-ethoxy-1-ethoxymethyl-ethyl) ester O'-(4-methanesulfinyl-phenyl) ester O''-methyl ester 
• 28248-55-7 Thiophosphoric acid O-(2-ethoxy-1-ethoxymethyl-ethyl) ester O'-methyl ester O''-(4-methylsulfanyl-phenyl) ester 
• 28372-34-1 Thiophosphoric acid O-(2-ethoxy-1-ethoxymethyl-ethyl) ester O'-methyl ester O''-(4-nitro-phenyl) ester 

Relevant articles and documents

Ecotoxicity studies of glycerol ethers in Vibrio fischeri: checking the environmental impact of glycerol-derived solvents

The toxicities of a series of glycerol mono-, di-, and trialkyl ethers against Vibrio fischeri bacteria have been determined. A systematic study has been carried out and the possible structure-toxicity relationships have been discussed using different QSAR models. Inhibition of bioluminescence after 30 minutes of exposure shows relatively low toxicity of many of the glycerol derived chemicals studied. Results indicate that, as a general rule, the ecotoxicity increases with the length and number of substituents. However, if the size of the molecule increases, an extra substituent at position 2 makes the toxicity lower than that of the corresponding analogues.

COMPOSITIONS FOR USE AS FUELS COMPRISING DERIVATIVES OF GLYCEROL

An object of the present invention relates to a composition that can be used as fuel comprising: at least one hydrocarbon mixture at least one compound having formula (I) X- CH(Y) -CH2OR (I) wherein R is a C1-C8 alkyl X is selected from H and OCH(CH2OR) and Y is CH2OR or X and Y jointly correspond to the substituent =CH-OR. Said composition can be advantageously used as fuel for diesel or gasoline engines.

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic

Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R1 represents hydrogen, OH, alkyl or phenyl alkyl,R2, R3, R4, and R5 represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, andQ represents a group selected from the following groups (i) to (iv), halogen, or alkoxy: