404337-42-4 Usage
Description
5-Chloro-2-iodo-M-xylene is a halogenated aromatic hydrocarbon derivative of xylene, featuring chlorine and iodine substitutions on the benzene ring. It is recognized for its reactivity, solubility in organic solvents, and versatility as a building block in chemical reactions and processes.
Uses
Used in Pharmaceutical Industry:
5-Chloro-2-iodo-M-xylene serves as an intermediate in the production of various pharmaceuticals, contributing to the synthesis of diverse medicinal compounds due to its unique structural features and reactivity.
Used in Agrochemical Industry:
5-Chloro-2-iodo-M-xylene is utilized as an intermediate in the development of agrochemicals, playing a role in the creation of substances designed to enhance crop protection and agricultural productivity.
Used in Fine Chemicals Production:
5-Chloro-2-iodo-M-xylene is employed in the synthesis of other fine chemicals, where its specific properties are leveraged to produce high-quality specialty chemicals for various applications.
Used in Organic Compounds Synthesis:
As a versatile intermediate, 5-Chloro-2-iodo-M-xylene is commonly used in the synthesis of a wide range of organic compounds, showcasing its utility across different chemical reactions.
Used in Research and Development:
Possessing potential applications in research and development, 5-Chloro-2-iodo-M-xylene aids in advancing the field of organic chemistry and chemical synthesis, facilitating the discovery and innovation of new chemical processes and products.
Check Digit Verification of cas no
The CAS Registry Mumber 404337-42-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,4,3,3 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 404337-42:
(8*4)+(7*0)+(6*4)+(5*3)+(4*3)+(3*7)+(2*4)+(1*2)=114
114 % 10 = 4
So 404337-42-4 is a valid CAS Registry Number.
404337-42-4Relevant articles and documents
Conformationally constrained analogues of N-(piperidinyl)-5-(4- chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): Design, synthesis, computational analysis, and biological evaluations
Zhang, Yanan,Burgess, Jason P.,Brackeen, Marcus,Gilliam, Anne,Mascarella, S. Wayne,Page, Kevin,Seltzman, Herbert H.,Thomas, Brian F.
experimental part, p. 3526 - 3539 (2009/04/07)
Structure-activity relationships (SARs) of 1 (SR141716) have been extensively documented, however, the conformational properties of this class have received less attention. In an attempt to better understand ligand conformations optimal for receptor recognition, we have designed and synthesized a number of derivatives of 1, including a four-carbon-bridged molecule (11), to constrain rotation of the diaryl rings. Computational analysis of 11 indicates a ～20 kcal/mol energy barrier for rotation of the two aryl rings. NMR studies have determined the energy barrier to be ～18 kcal/mol and suggested atropisomers could exist. Receptor binding and functional studies with these compounds displayed reduced affinity and potency when compared to 1. This indicates that our structural modifications either constrain the ring systems in a suboptimal orientation for receptor interaction or the introduction of steric bulk leads to disfavored steric interactions with the receptor, and/or the relatively modest alterations in the molecular electrostatic potentials results in disfavored Coulombic interactions.
