404369-26-2

Upstream product

• 302593-18-6 methyl 2-deoxy-3,4-O-isopropylidene-2-[(9-phenyl-9-fluorenyl)-amino]-D-arabinonate 
• 302593-20-0 methyl 2-deoxy-3,4-O-isopropylidene-5-O-methanesulfonyl-2-[(9-phenyl-9-fluorenyl)-amino]-D-arabinonate 

Downstream Products

• 404369-29-5 methyl (2R,3S)-3-(tert-butyldimethylsilyl)oxy-5-hydroxy-2-[(9-phenyl-9-fluorenyl)-amino]-pentanoate 
• 404369-30-8 cis-3-O-(tert-butyldimethylsilyl)-1-(9-phenyl-9-fluorenyl)-D-proline methyl ester 
• 404369-28-4 methyl (2R,3S)-3-(tert-butyldimethylsilyl)oxy-2-[(9-phenyl-9-fluorenyl)-amino]-4-pentenoate 
• 404369-27-3 methyl (2R,3S)-3-hydroxy-2-[(9-phenyl-9-fluorenyl)-amino]-4-pentenoate 

Relevant academic research and scientific papers

Efficient synthesis of 3-hydroxyprolines and 3-hydroxyprolinols from sugars

trans-3-Hydroxy-L-proline 1, trans-3-hydroxy-L-prolinol 2, cis-3-hydroxy-D-proline 3, and cis-3-hydroxy-D-prolinol 4 have been prepared in enantiomerically pure form with chirospecific manner. Key intermediates, 2-amino-3-hydroxy-4-pentenoate 9 and 17, were obtained from D-glucono-δ-lactone and L-gulonic acid γ-lactone via a simultaneous dealkoxyhalogenation.